Effect of isoquinoline alkaloids of different structural types on antiplatelet aggregation in vitro
Journal
Planta Medica
Journal Volume
72
Journal Issue
13
Pages
1238-1241
Date Issued
2006
Author(s)
CHE-MING TENG
Abstract
Forty-one isoquinoline alkaloids were tested for antiplatelet aggregation effects. Among them, (-)-discretamine (6), protopine (7), ochotensimine (18), O-methylarmepavinemethine (23), lindoldhamine (25), isotetrandrine (26), thalicarpine (27), papaverine (28), and D-(+)- N-norarmepavine (32) exhibited significant inhibitory activity towards adenosine 5'-diphosphate (ADP)-, arachidonic acid (AA)-, collagen-, and/or platelet-activating factor (PAF)-induced platelet aggregation. The results are discussed on the basis of structure-activity relationships.
SDGs
Type
journal article