SARS-CoV-2 Positivity, Stent Thrombosis, and 30-day Mortality in STEMI Patients Undergoing Mechanical Reperfusion
Journal
Angiology
Date Issued
2022-10-12
Author(s)
De Luca, Giuseppe
Algowhary, Magdy
Uguz, Berat
Oliveira, Dinaldo C
Ganyukov, Vladimir
Zimbakov, Zan
Cercek, Miha
Okkels Jensen, Lisette
Loh, Poay Huan
Calmac, Lucian
Roura I Ferrer, Gerard
Quadros, Alexandre
Milewski, Marek
Scotto Di Uccio, Fortunato
von Birgelen, Clemens
Versaci, Francesco
Ten Berg, Jurrien
Casella, Gianni
Wong Sung Lung, Aaron
Kala, Petr
Díez Gil, José Luis
Carrillo, Xavier
Dirksen, Maurits
Becerra-Munoz, Victor M
Kang-Yin Lee, Michael
Juzar, Dafsah Arifa
de Moura Joaquim, Rodrigo
De Simone, Ciro
Milicic, Davor
Davlouros, Periklis
Bakraceski, Nikola
Zilio, Filippo
Donazzan, Luca
Kraaijeveld, Adriaan
Galasso, Gennaro
Arpad, Lux
Marinucci, Lucia
Guiducci, Vincenzo
Menichelli, Maurizio
Scoccia, Alessandra
Yamac, Aylin Hatice
Ugur Mert, Kadir
Flores Rios, Xacobe
Kovarnik, Tomas
Kidawa, Michal
Moreu, Josè
Flavien, Vincent
Fabris, Enrico
Lozano Martínez-Luengas, Iñigo
Boccalatte, Marco
Bosa Ojeda, Francisco
Arellano-Serrano, Carlos
Caiazzo, Gianluca
Cirrincione, Giuseppe
Sanchis Forés, Juan
Vignali, Luigi
Pereira, Helder
Manzo-Silbermann, Stephane
Ordoñez, Santiago
Arat Özkan, Alev
Scheller, Bruno
Lehtola, Heidi
Teles, Rui
Mantis, Christos
Antti, Ylitalo
Brum Silveira, João António
Bessonov, Ivan
Zoni, Rodrigo
Savonitto, Stefano
Kochiadakis, George
Alexopoulos, Dimitrios
Uribe, Carlos E
Kanakakis, John
Faurie, Benjamin
Gabrielli, Gabriele
Gutierrez Barrios, Alejandro
Bachini, Juan Pablo
Rocha, Alex
Tam, Frankie Chor-Cheung
Rodriguez, Alfredo
Lukito, Antonia Anna
Bellemain-Appaix, Anne
Pessah, Gustavo
Cortese, Giuliana
Parodi, Guido
Burgadha, Mohammed Abed
Kedhi, Elvin
Lamelas, Pablo
Suryapranata, Harry
Nardin, Matteo
Verdoia, Monica
Abstract
SARS-Cov-2 has been suggested to promote thrombotic complications and higher mortality. The aim of the present study was to evaluate the impact of SARS-CoV-2 positivity on in-hospital outcome and 30-day mortality in ST-segment elevation myocardial infarction (STEMI) patients undergoing primary percutaneous coronary intervention (PCI) enrolled in the International Survey on Acute Coronary Syndromes ST-segment elevation Myocardial Infarction (ISACS-STEMI COVID-19 registry. The 109 SARS-CoV-2 positive patients were compared with 2005 SARS-CoV-2 negative patients. Positive patients were older (P = .002), less often active smokers (P = .002), and hypercholesterolemic (P = .006), they presented more often later than 12 h (P = .037), more often to the hub and were more often in cardiogenic shock (P = .02), or requiring rescue percutaneous coronary intervention after failed thrombolysis (P < .0001). Lower postprocedural Thrombolysis in Myocardial Infarction 3 flow (P = .029) and more thrombectomy (P = .046) were observed. SARS-CoV-2 was associated with a significantly higher in-hospital mortality (25.7 vs 7%, adjusted Odds Ratio (OR) [95% Confidence Interval] = 3.2 [1.71-5.99], P < .001) in-hospital definite in-stent thrombosis (6.4 vs 1.1%, adjusted Odds Ratio [95% CI] = 6.26 [2.41-16.25], P < .001) and 30-day mortality (34.4 vs 8.5%, adjusted Hazard Ratio [95% CI] = 2.16 [1.45-3.23], P < .001), confirming that SARS-CoV-2 positivity is associated with impaired reperfusion, with negative prognostic consequences.
Subjects
STEMI; outcome; thrombosis
SDGs
Publisher
SAGE PUBLICATIONS INC
Type
journal article