VARIABILITY IN AFLATOXIN-ALBUMIN ADDUCT LEVELS AND EFFECTS OF HEPATITIS B AND C VIRUS INFECTION AND GLUTATHIONE S-TRANSFERASE M1 AND T1 GENOTYPE
Resource
ENVIRONMENTAL HEALTH PERSPECTIVES v.109 n.8 pp.833-837
Journal
ENVIRONMENTAL HEALTH PERSPECTIVES
Journal Volume
v.109
Journal Issue
n.8
Pages
833-837
Date Issued
2001
Date
2001
Author(s)
WANG, LI-YU
CHEN, CHIEN-JEN
Abstract
Exposure to aflatoxin B-1 (AFB(1)), an important cofactor in
the etiology of hepatocellular carcinoma in Taiwan, is
influenced by dietary and other factors. The present study
examined the intraindividual variability in AFB(1)-albumin
adducts, the most reliable long-term biomarker of AFB(1)
exposure, and whether the baseline or follow-up adduct
levels and the intraindividual variability in adduct levels
are modified by endogenous and environmental factors. The
study measured AFB(1)-albumin adduct levels among 264
healthy male residents of three townships (Hu-Hsi, Ma-Kung,
and Pai-Hsa) of Penghu Islets, Taiwan, at two different time
points with a median interval of 1.68 years (range 1.00-3.
17 years). There was a generalized reduction in the adduct
levels, with the median values being 22.1 pmol/mg (range 5.0
-355.8 pmol/mg) at time 1 and 14.3 pmol/mg (range 5.0-205.2
pmol/mg) at time 2. This intraindividual variability in
adduct levels was inversely associated with the age of
subjects and the tirne interval between the two blood draws.
The variability in adduct levels was lower among subjects
in Hu-Hsi and Pai-Hsa townships as compared to those in Ma-
Kung. No significant association was observed for the
intraindividual variability in AFB(1)-albumin adducts with
regard to the season when blood was drawn. There was also no
significant association between intraindividual variability
and hepatitis B surface antigen, anti-hepatitis C virus (
anti-HCV, glutathione S-transferase (GST) M1, or GSTT1
status. In conclusion, we found substantial intraindividual
variability in the AFB(1) exposure (as determined by AFB(1)-
albumin adducts) in Taiwan, which was probably more likely
related to dietary or other environmental influences rather
than to endogenous factors (e.g., hepatitis B/C viral
infection or GST M1/T1 genetic status).
Subjects
aflatoxin-albumin adducts
biomarkers
intraindividual variability
liver cancer
molecular epidemiology
SDGs
Type
journal article