環境職業生殖危害（V）—液晶顯示器製造女性員工生殖內分泌研究
Date Issued
2005-07-31
Date
2005-07-31
Author(s)
陳保中
DOI
932320B002088
Abstract
Assays of prospectively collected daily urine samples for metabolites of reproductive
endocrine such as follicle stimulating hormone (FSH), estrogens, and progesterone have been used in much epidemiologic studies to assess ovulatory status, timing of ovulation and
menstrual function. Previous epidemiologic studies have examined the effects of
phychological stress in work place, smoking, and occupation on menstrual function by
using daily urinary hormone metabolites. In this study, we used this tool to estimate the
length of segment, ovulatory status, and hormone levels. By the assessment, we could
determine the target organs of the occupational exposure.
The objective of this cross-sectional study was to assess the potential reproductive
endocrine effects of occupational exposure in the LCD manufacturing. Menstrual function
was estimated by questionnaire. Reproductive endocrine was evaluated by detecting the
concentration of reproductive hormonal metabolites in urine, either questionnaire or daily
diary. Furthermore, we used handheld volatile organic compound (VOC) monitor and 24
hours canister sampling to assess potential chemical exposure. Electric and magnetic field
exposure data were collected from an EMDEX meter.
The study population consisted of female employees in a LCD plant in Taiwan. About 256
female workers have completed the questionnaire during the end of 2003. They were
screened by a face-to-face interview to identify those who were eligible and willing to
collect and freeze urine samples daily after waking for up to 1.5 menstrual cycles. Finally,
urine samples of 96 subjects were included in urinary hormone analysis. Participants
completed a detailed baseline questionnaire. We assayed FSH, E1C (estrone conjugates) and
PdG (pregnanediol-3-glucuronide) by ELISA. We also obtained reproductive and exposure
information from baseline questionnaire and daily diary.
After adjusting effects of factors on hormonal excretion, E1C level of the female workers in
module group still had a significantly increased (2.38 ng/mg Cr, 95% CI: 0.25, 4.51)
compared with the female workers in panel group in early follicular phase. FSH level of the
women in module group had a little significantly increased (0.08 mIU/mg Cr, 95% CI: 0.00,
0.16) adjusted by effects compared with the women in panel group in early follicular phase.
The possibility is that multiple chemical exposures may diminish ovarian oocyte reserve or
induced ovarian failure. Furthermore, shorten follicular phase may lead to shorten menstrual
cycle. It is consistent with the finding of our previous study.
Subjects
estrogens
follicle stimulating hormone
infertility
female
liquid crystal display
manufacturing
manufacturing
luteinizing hormone
menstruation
progesterone
Publisher
臺北市：國立臺灣大學公共衛生學院職業醫學與工業衛生研究所
Type
report
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