Multifunctional core-shell-corona-type polymeric micelles for anticancer drug-delivery and imaging
Journal
Chemistry - A European Journal
Journal Volume
19
Journal Issue
15
Pages
4812-4817
Date Issued
2013
Author(s)
Abstract
We have developed core-shell-corona-type polymeric micelles that can integrate multiple functions in one system, including the capability of accommodating hydrophobic dyes into core and hydrophilic drug into the shell, as well as pH-triggered drug-release. The neutral and hydrophilic corona sterically stabilizes the multifunctional polymeric micelles in aqueous solution. The mineralization of calcium phosphate (CaP) on the PAA domain not only enhances the diagnostic efficacy of organic dyes, but also works as a diffusion barrier for the controlled release. Sustained strategy delivers: A facile strategy for fabricating multifunctional polymeric micelles for anticancer drug-delivery and imaging is presented (see figure). Cisplatin can be incorporated into the shell of polymeric micelles that have an imaging agent already encapsulated for visualizing the pH-triggered drug release. The neutral and hydrophilic corona sterically stabilizes the multifunctional polymeric micelles in aqueous solution for long-term circulation in the human body. Copyright ? 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Subjects
cancer; cisplatin; drug delivery; fluorescent probes; micelles
SDGs
Other Subjects
cancer; Cis-platin; Controlled release; Fluorescent probes; Hydrophilic corona; Hydrophilic drugs; Multiple function; Polymeric micelle; Drug delivery; Hydrophilicity; Micelles; Platinum compounds; Shells (structures); Solutions; Polymers; antineoplastic agent; calcium phosphate; cisplatin; polymer; article; cell strain HepG2; chemical phenomena; chemistry; drug delivery system; human; methodology; micelle; pH; synthesis; Antineoplastic Agents; Calcium Phosphates; Cisplatin; Drug Delivery Systems; Hep G2 Cells; Humans; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Micelles; Polymers
Type
journal article