α-Glucosidase inhibitors from the seeds of Syagrus romanzoffiana
Journal
Phytochemistry
Journal Volume
69
Journal Issue
5
Pages
1173-1178
Date Issued
2008
Author(s)
Abstract
Bioassay-guided fractionation against α-glucosidase resulted in isolation and characterization of eight active compounds from the EtOH extract of the seeds of Syagrus romanzoffiana. Of these, seven are stilbenoids, and two of them, 13-hydroxykompasinol A (1) and scirpusin C (4), possess potent inhibitory activity against α-glucosidase type IV from Bacillus stearothermophilus with the IC50 value of 6.5 and 4.9 μM, respectively. The in vivo assay on normal Wistar rats using oral sucrose challenge also demonstrated that kompasinol A (2) and 3,3′,4,5,5′-pentahydroxy-trans-stilbene (5) possess significant effect in reducing the postprandial blood glucose level (10.2% and 12.1% at 10 mg/kg, respectively). These results suggest that stilbenoids might be explored for their therapeutic potential as hypoglycemic agents. ? 2007 Elsevier Ltd. All rights reserved.
Subjects
α-Glucosidase inhibitor; 13-Hydroxykompasinol A; Arecaceae; Scirpusin C; Stilbenoids; Syagrus romanzoffiana; Type 2 diabetes
SDGs
Other Subjects
13 hydroxykompasinol A; 13-hydroxykompasinol A; alpha glucosidase; antidiabetic agent; enzyme inhibitor; plant extract; scirpusin C; stilbene derivative; unclassified drug; animal; Arecaceae; article; chemistry; conformation; dose response; drug antagonism; drug effect; enzyme activation; enzymology; Geobacillus stearothermophilus; glucose blood level; isolation and purification; methodology; nuclear magnetic resonance spectroscopy; oral drug administration; plant seed; rat; standard; stereoisomerism; time; Wistar rat; Administration, Oral; alpha-Glucosidases; Animals; Arecaceae; Bacillus stearothermophilus; Blood Glucose; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Hypoglycemic Agents; Magnetic Resonance Spectroscopy; Molecular Conformation; Plant Extracts; Rats; Rats, Wistar; Reference Standards; Seeds; Stereoisomerism; Stilbenes; Time Factors; Arecaceae; Geobacillus stearothermophilus; Rattus norvegicus; Syagrus romanzoffiana
Type
journal article