https://scholars.lib.ntu.edu.tw/handle/123456789/108115
標題: | ANDROGEN RECEPTOR EXON 1 CAG REPEAT LENGTH AND RISK OF HEPATOCELLULAR CARCINOMA IN WOMEN | 作者: | YU, MING-WHEI | 關鍵字: | HEPATITIS-B CARRIERS;PROSTATE-CANCER CELLS;S-TRANSFERASE M1;BREAST-CANCER;TRANSGENIC MICE;GENETIC SUSCEPTIBILITY | 公開日期: | 2002 | 卷: | v.36 | 期: | n.1 | 起(迄)頁: | 156-163 | 來源出版物: | HEPATOLOGY | 摘要: | The androgen receptor (AR) gene is localized on chromosome X , and shorter CAG repeats in exon 1 of the AR gene were recently suggested to increase hepatitis B virus (HBV)- related hepatocellular carcinoma (HCC) risk among men. To examine whether the relationship between the AR-CAG repeats and HCC was also evident among women, we conducted a case- control study in Taiwan. The number of AR-CAG repeats was determined for 238 women with HCC and 354 unrelated control subjects (comprising 188 first-degree and 166 nonbiological relatives) selected from female relatives of patients with HCC. Women harboring 2 AR alleles with more than 23 CAG repeats had an increased risk of HCC (age-adjusted odds ratio [OR], 1.82; 95% CI, 1.06-3.14), compared with women with only short alleles or a single long allele. The association between harboring 2 AR alleles containing longer CAG repeats and HCC was more striking among HBV carriers ( age-adjusted OR for more than 22 repeats, 2.23; 95% CI, 1.14 -4.34) and particularly prominent among HBV carriers under age 53 years (age-adjusted OR, 3.16; 95% CI, 1.13-8.82). When CAG repeats were analyzed as a continuous variable, the increase in HCC risk associated with each incremental repeat in the shorter of 2 alleles in a given genotype was statistically significant among women with a first-degree relative with HCC (age-adjusted OR, 1.18; 95% CI, 1.01-1.37) . No such relationship was detected among women without the family history. In conclusion, our observations suggest that the AR-CAG alleles may contribute to HCC predisposition among women through a mechanism different from that for men . |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/80692 |
顯示於: | 公共衛生學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。