https://scholars.lib.ntu.edu.tw/handle/123456789/108168
標題: | ROLE OF REPRODUCTIVE FACTORS IN HEPATOCELLULAR CARCINOMA: IMPACT ON HEPATITIS B- AND C-RELATED RISK | 作者: | YU, MING-WHEI | 關鍵字: | ORAL-CONTRACEPTIVES;LIVER-CANCER;TRANSGENIC MICE;BREAST- CANCER;HORMONE DEPENDENCY;ESTROGEN-RECEPTORS | 公開日期: | 2003 | 卷: | v.38 | 期: | n.6 | 起(迄)頁: | 1393-1400 | 來源出版物: | HEPATOLOGY | 摘要: | Hepatocellular carcinoma (HCC) is more prevalent in men than in women. Estrogen may play some role in the development of HCC. We conducted a multicenter case-control study to evaluate the effects of reproductive factors on HCC risk, and to assess whether the association between each factor and HCC differs between hepatitis B surface antigen ( HBsAg)- positive and -negative women, in which hepatitis C virus ( HCV) is the major cause of HCC. The study included 218 women with HCC and 729 control women selected from nonbiological and first-degree female relatives of patients with HCC. The risk of HCC was inversely related to the number of full-term pregnancies (FTP) (P-trend = .0216) anti age at natural menopause (P-trend = .0251 among women aged 45-55 without prior surgical menopause). Oophorectorny at age less than or equal to50 during premenopausal years was also a risk factor (multivariate-adjusted OR, 2.57; 95% CI, 1.42-4.63). Use of hormone replacement therapy (HRT) ( multivariate- adjusted OR, 0.46; 95% CI, 0.27-0.79) was associated with a lower risk of HCC, and there was a trend in the risk with increasing duration of HRT (P-trend = 0. 0013). All reproductive factors had a similar impact on HBsAg-positive and -negative women except for an early menarche (:512 vs. 2 :16 years), which increased HCC risk in HBsAg carriers ( multivariate-adjusted OR, 6.96; 95% CI, 2. 52-19.18) hut posed no increased risk in noncarriers (P- interaction = . 0053). In conclusion, increased exposure to estrogen during adulthood may provide a protective effect against HCC. Nevertheless, an early menarche, which results in early estrogen exposure, does not confer protection for HBsAg carriers. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/80918 |
顯示於: | 公共衛生學系 |
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