DC 欄位 | 值 | 語言 |
dc.contributor | 鄭尊仁 | zh-TW |
dc.contributor | 臺灣大學:職業醫學與工業衛生研究所 | zh-TW |
dc.contributor.author | 李偉量 | zh-TW |
dc.contributor.author | Li, Wei-Liang | en |
dc.creator | 李偉量 | zh-TW |
dc.creator | Li, Wei-Liang | en |
dc.date | 2008 | en |
dc.date.accessioned | 2010-05-11T03:35:31Z | - |
dc.date.accessioned | 2018-06-29T17:23:51Z | - |
dc.date.available | 2010-05-11T03:35:31Z | - |
dc.date.available | 2018-06-29T17:23:51Z | - |
dc.date.issued | 2008 | - |
dc.identifier.other | U0001-2807200805454300 | en |
dc.identifier.uri | http://ntur.lib.ntu.edu.tw//handle/246246/182319 | - |
dc.description.abstract | 流行病學研究指出,大氣微粒會造成心臟衰竭住院率及死亡率的上升。但探討微粒與心臟衰竭相關相關性之毒理研究仍相當有限。因此本研究欲針對心室受損之大鼠暴露在大氣微粒的心臟毒性進行探討。研究可概分為兩大部分一部分:利用氣管灌注的方式,將注射isoproterenol後產生心肌損傷大鼠,分別在一周及八周後暴露大氣PM2.5微粒、PM10微粒及生理食鹽水之控制組,以心臟超音波觀察其心臟的急性及慢性效應。研究結果未呈現一致性的微粒急性效應;此外,微粒的慢性效應在本研究中也未發現。但由於測量工具及研究設計部分之限制,暴露大氣微粒是否造成心肌受損大鼠心室功能下降之效應及其詳細機轉,仍待未來研究深入探討之。二部分:以細粒徑微粒濃縮器進行微粒的長期暴露,利用心肌損傷後大鼠亞慢性暴露大氣濃縮微粒的心臟毒性,並檢視該濃縮微粒系統長期使用之效能及穩定性。將注射isoproterenol後產生心肌損傷大鼠三天後進行全身性呼吸暴露,以吸入大氣濃縮微粒為暴露組,呼吸過濾空氣之實驗動物為對照組,進行為期一個月、每周四天,每天五小時的連續暴露,並分別在暴露前、暴露後兩周及四周後進行尾部靜脈採血測定心肌損傷及心臟衰竭程度。研究結果發現,大氣濃縮微粒暴露會使心臟衰竭功能指標BNP較慢恢復到穩定值,但心肌損傷指標cTnI卻無發現這樣的結論,顯示大氣微粒可能在急性暴露下會有毒性效應,但其詳細作用時間及機轉仍待未來研究進一步探討。 | zh-TW |
dc.description.abstract | Numerous epidemiologic studies have shown that the mortality and hospital admissions of heart failure are associated with ambient particle. However, the toxicological researches on the relationship between ambient particle and heart failure are limited. Thus, we used an animal model of myocardial injury to investigate the cardiovascular toxicity of ambient particle. Our study are composed of two major parts:art Ⅰ:Rats were received 150 mg/kg isoproterenol by subcutaneous injection to induce myocardial injury. Then, rats were exposed to PM2.5、PM10 and saline by intratracheal instillation one and eight weeks after the injection of ISO. The acute and chronic cardiovascular effects were observed using echocardiography. The results showed that acute PM2.5 exposure would lead to decreased LV function, but the similar effects were not observed in PM10. Further, we didn’t observe chronic effect of particles. Because of limitations of echocardiography and study design, the exact relationship between ambient particle and heart failure need further study.art Ⅱ:Ultrafine particle concentrator (UFPC) was used to conduct a subchronic exposure in rats administered with 150 mg/kg of isoproterenol by subcutaneous injection. Animals were exposed to concentrated ambient particles (CAPs) for 5-hr/day, 4-day/week for 4-weeks, and controls were exposed to filtered air (FA). BNP for left ventricular function status and cTnI for myocardial injury were measured before exposure, 2 and 4 weeks after exposure. Results of BNP concentration suggest that animals exposed to CAPs may return to normal level later than FA group. As to cTnI, PM didn’t induce further myocardial injury at both CAPs and FA group. Our results suggest that CAPs may cause LV dysfunction shortly after myocardial injury. | en |
dc.description.tableofcontents | 致謝 I錄 II目錄 IV目錄 V要 1bstract 2、研究目的 4、文獻探討 5-1 微粒流行病學研究 5-2 粒狀空氣污染物的心血管健康效應 6-3 微粒易感受性族群 6-4 心臟衰竭 6-5 心臟衰竭之病生理 7-6 微粒導致心衰竭之流行病學與毒理學研究 7-7急性心肌梗塞與微粒空氣汙染 8-8 濃縮大氣微粒的健康相關研究 9-9 氣管灌注與呼吸暴露方式比較 10-10 細粒徑微粒濃縮器 10-11 心臟衰竭疾病動物模式 11-12 心臟衰竭及心肌損傷評估指標 12-12-1 心臟超音波 12-12-2 Brain Natriuretic Peptide, BNP 12-12-3 Troponin 13、氣管灌注大氣微粒對心肌受損大鼠之左心室功能研究 14-1 摘要 15-2 背景 16-3 材料與方法 17-3-1 實驗動物 17-3-2 微粒蒐集與製備 17-3-3 實驗流程 18-3-4 氣管內灌注(Intratracheal Installation, IT)暴露模式 18-3-5 心臟超音波 18-3-6 統計分析 19-4 結果 20-4-1 實驗動物基本特性及心臟肥大程度 20-4-2 微粒急性效應 20-4-3 微粒慢性效應 20-5 討論 22-6 結論與建議 25-7 表格與圖片 26、亞慢性呼吸暴露大氣微粒對心肌受損大鼠之心血管效應 34-1 摘要 35-2 背景 36-3 材料與方法 37-3-1 UFPC細粒徑微粒濃縮器 37-3-2 全身暴露系統 (Whole-Body Exposure System) 37-3-3 實驗流程 38-3-4 BNP與Troponin之測定 38-4-5 統計分析方法 38-4 結果 39-4-1 UFPC系統 39-4-2 全身暴露系統 39-4-3 實驗動物基本特性 39-4-4 BNP 40-4-5 Troponin I 40-5 討論 41-6 結論與建議 45-7 表格與圖片 46、參考文獻 56 | en |
dc.format | application/pdf | en |
dc.format.extent | 1989593 bytes | - |
dc.format.mimetype | application/pdf | - |
dc.language | zh-TW | en |
dc.language.iso | en_US | - |
dc.subject | 心臟衰竭 | zh-TW |
dc.subject | 心肌損傷 | zh-TW |
dc.subject | 超音波 | zh-TW |
dc.subject | BNP | zh-TW |
dc.subject | Troponin I | zh-TW |
dc.subject | 大氣濃縮微粒 | zh-TW |
dc.subject | 細粒徑微粒濃縮器 | zh-TW |
dc.subject | Heart failure | en |
dc.subject | Myocardial injury | en |
dc.subject | Echocardiography | en |
dc.subject | CAPs | en |
dc.subject | UFPC | en |
dc.title | 大氣微粒對心肌受損大鼠之心血管毒性研究 | zh-TW |
dc.title | Cardiovascular Toxicity of Ambient Particles in Rats with Myocardial Injury | en |
dc.type | thesis | en |
dc.identifier.uri.fulltext | http://ntur.lib.ntu.edu.tw/bitstream/246246/182319/1/ntu-97-R95841017-1.pdf | - |
item.cerifentitytype | Publications | - |
item.languageiso639-1 | en_US | - |
item.openairetype | thesis | - |
item.fulltext | with fulltext | - |
item.grantfulltext | open | - |
item.openairecristype | http://purl.org/coar/resource_type/c_46ec | - |
顯示於: | 環境與職業健康科學研究所
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