https://scholars.lib.ntu.edu.tw/handle/123456789/111831
標題: | Effect of Obesity, Physical Activity, and Cardiorespiratory Fitness on Blood Pressure, Inflammation, and Insulin Resistance in the National Health and Nutrition Survey 1999-2002 | 作者: | LIN, CHIEN-YU CHEN, PAU-CHUNG |
公開日期: | 2010 | 起(迄)頁: | - | 來源出版物: | NUTRITION, METABOLISM AND CARDIOVASCULAR DISEASES v.20 n.10 pp.713-719 | 摘要: | BACKGROUND AND AIMS: This study was designed to elucidate the effects of obesity, self-reported physical activity and cardiorespiratory fitness on blood pressure, inflammation, and insulin resistance. METHODS AND RESULTS: Data from 950 Caucasian subjects ranging in age from 19 to 49 years from the National Health and Nutrition Survey (NHANES), 1999-2002 , were included to construct a population-based observational study. Cardiorespiratory fitness (VO(2) max) was predicted from a submaximal exercise stress test. Self- reported physical activity was measured by metabolic equivalent score transformed from a questionnaire. A structural equation model (SEM) was developed to examine the relationship between obesity, cardiorespiratory fitness, self-reported physical activity, and hypertension, inflammation, and insulin resistance. The model showed that obesity was positively linked to hypertension (B=0.50, P<0. 001) and C- reactive protein (CRP; B=0.15, p<0.05), which in turn led to insulin resistance (B=0.44, P<0.05). Increased cardiorespiratory fitness was negatively associated with CRP ( =-0.23, P<0.01), but not correlated to hypertension after adjustment for potential confounding factors. No significant association was found between self-reported physical activity and hypertension, insulin resistance, and CRP. CONCLUSION: Obesity contributes to the development of hypertension, inflammation, and insulin resistance. Improved cardiorespiratory fitness might lead to clinical and biochemical improvement in insulin resistance by reducing the inflammatory state. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/235869 |
顯示於: | 環境與職業健康科學研究所 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。