Associations between Human Papillomavirus and Female Lung and Breast Cancers in Taiwan
Date Issued
2006
Date
2006
Author(s)
Lin, Chi-Chen
DOI
zh-TW
Abstract
Introduction: Cancers of lung and breast were major threats to women’ lives in Taiwan. Less than 50% of risk could be attributed to major risk factors, such as smoking to lung cancer as well as family history, obesity and female hormone to breast cancer. Since human papillomavirus (HPV) was ever proposed a positive association with lung/breast cancer by few cross-sectional case-series or case-control studies. For better temporality in causal inference, a long-term follow-up study using a community-based female cohort was subject of the role of HPV infection in cancer development of lung and breast.
Method: A prospective cohort study of 10615 female participants (aged 30-64 years), who received examination of Pap smear and cervical cell collection at enrollment, recruited to a community-based cancer screening program in 1991-1992. HPV DNA and genotypes were performed by polymerase chain reactions and HPV Blot. Cox proportional hazards model was used to estimate HPV type-specific risk ratio (RR) and their confidence intervals (CIs) of lung/breast cancer with multiple adjustment.
Result: HPV types of 11, 74, CP8304, MM4, 16, 45, 35, 43, 51 and MM8 were suggested as high-risk types (RR>=2) for lung cancer. The adjusted RR was 2.7 (95%CI:1.5-5.1) for women infected with any one of these types to develop lung cancer during follow-up. Considering high-risk types for breast cancer (HPV39, 42, CP8304, 51, CP8061, 55 and 66), its RR was 2.7(95%CI:1.5-4.7). Consistently, the RRs were about 3-fold for both sites of cancer while subjects with abnormal cervix further excluded. We also found that HPV 11, 74, CP8304, MM4, 45 and 35 were strongly associated with lung adenocarcinoma, and its RR (95% C.I.) was 5.4(2.1-13.6).
Subjects
人類乳突病毒
肺癌
乳癌
Human papillomavirus
Lung cancer
Breast cancer
SDGs
Type
thesis
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