dc.relation.reference | 1. Chen DS. From hepatitis to hepatoma: lessons from type B viral hepatitis. Science 1993;336:369-70.
2. Lee WM. Hepatitis B virus infection. N Engl J Med 1997;337:1733-45.
3. Dane DS, Cameron CH, Briggs M. Virus- like particles in the serum of patients with Australia-antigen-associated hepatitis. Lancet 1970;1:695-8.
4. Kao JH. Hepatitis B viral genotypes: clinical relevance and molecular characteristics. J Gastroenterol Hepatol 2002;17:643-50.
5. Ganem D. Assembly of hepadnaviral virions and subviral particles. Curr Top Microbiol Immunol 1991;168:61-83.
6. Ganem D, Schneider RJ. Hepadnaviridae: the viruses and their replication. In: Knipe DM, Howley PM, eds. Fields virology, 4th ed. Vol. 2. Philadelphia: Lippincott Williams & Wilkins, 2001:2923-69.
7. Klingmuller U, Schaller H. Hepadnavirus infection requires interaction between the viral pre-S domain and a specific hepatocellular receptor. J Virol 1993;67:7414-22.
8. Magnius LO, Espmark JA. New specificities in Australia antigen positive sera distinct from the Le Bouvier determinants. J Immunol 1972;109:1017-21.
9. Bertoletti A, Ferrari C, Fiaccadori F, Penna A, et al. HLA class I-restricted human cytotoxic T cells recognize endogenously synthesized hepatitis B virus nucleocapsid antigen. Proc Natl Acad Sci U S A 1991;88:10445-9.
10. Magnius LO, Lindholm A, Lundin P, Iwarson S. A new antigen-antibody system: clinical conference in long-term carriers of hepatitis B surface antigen. JAMA 1974;231:356-9.
11. Takahashi K, Akahane Y, Gotanda T, Mishiro T, et al. Demonstration of hepatitis B e antigen in the core of Dane particles. J Immunol 1979; 122:275-9.
12. Milich DR, Jones JE, Hughes JL, Price J, Raney AK, et al. Is a function of the secreted hepatitis B e antigen to induce immunologic tolerance in utero? Proc Natl Acad Sci U S A 1990;87:6599-6603.
13. Botha JF, Ritchie MJ, Dusheiko GM, Mouton HW, et al. Hepatitis B virus carrier state in black children in Ovamboland: role of perinatal and horizontal infection. Lancet 1984;1:1210-2.
14. Derso A, Boxall EH, Tarlow MJ, Flewett TH. Transmission of HBsAg from mother to infant in four ethnic groups. BMJ 1978;1:949-52.
15. Wong VC, Ip HM, Reesink HW, Lelie PN, et al. Prevention of the HBsAg carrier state in newborn infants of mothers who are chronic carriers of HBsAg and HBeAg by administration of hepatitis B vaccine and hepatitis B immunoglobulin. Double-blind randomised placebo-controlled study. Lancet 1984;1:921-6.
16. Milich D, Liang TJ. Exploring the biological basis of hepatitis B e antigen in hepatitis B virus infection. Hepatology 2003;38(5):1075-86.
17. Chang C, Enders G, Sprengel R, Peters N, et al. Expression of the precore region of an avian hepatitis B virus is not required for viral replication. J Virol 1987;61:3322-5.
18. Chen Y, Kew MC, Hornbuckle WE, Tennant BC, et al. The precore gene of the woodchuck hepatitis virus genome is not essential for viral replication in the natural host. J Virol 1992;66:5682-4.
19. Schlicht HJ, Salfeld J, Schaller H. The duck hepatitis B virus pre-C region encodes a signal sequence which is essential for synthesis and secretion of processed core proteins but not for virus formation. J Virol 1987;61: 3701-9.
20. Merican I, Guan R, Amarapuka D, Alexander MJ, et al. Chronic hepatitis B virus infection in Asian countries. J Gastroenterology and Hepatology 2000;15:1356-61.
21. Chang MH, Hsu HY, Ni YH, Tsai KS, et al. Precore stop codon mutation in chronic hepatitis B virus infection in children: its relation to hepatitis B e seroconversion and maternal hepatitis B surface antigen. J Hepatology 1998;28:915-22.
22. Milich DR, McLachlan A. The nucleocapsid of hepatitis B virus is both a T-cell-independent and a T-cell-dependent antigen. Science 1986;234: 1398-1401.
23. Kuhober A, Pudollek HP, Reifenberg K, Chisari FV, et al. DNA immunization induces antibody and cytotoxic T cell responses to hepatitis B core antigen in H-2b mice. J Immunol 1996;156:3687-95.
24. Ferrari C, Penna A, Bertoletti A, Valli A, et al. Cellular immune response to hepatitis B virus-encoded antigens in acute and chronic hepatitis B virus infection. J Immunol 1990;145:3442-9.
25. Jung MC, Diepolder HM, Spengler U, Wierenga EA, et al. Activation of a heterogeneous hepatitis B (HB) core and e antigen-specific CD4 T-cell population during seroconversion to anti-HBe and anti-HBs in hepatitis B virus infection. J Virol 1995;69:3358-68.
26. Milich DR, McLachlan A, Stahl S, Wingfield P, et al. Comparative immunogenicity of hepatitis B virus core and E antigens. J Immunol 1988;141:3617-24.
27. Milich DR, Schodel F, Hughes J, Jones JE, et al virus core and e antigen elicit different Th cell subsets: antigen structure can affect Th cell phenotype. J Virol 1997;71:2192-201.
28. Akahane Y, Yamanaka T, Suzuki H, Sugai Y, et al. Chronic active hepatitis with hepatitis B virus DNA and antibody against e antigen in serum. Disturbed synthesis and secreted of e antigen from hepatocytes due to a point mutation in the precore region. Gastroenterology 1990;99:1113-9.
29. Baron JL, Gardiner L, Nishimura S, Shinkai K, et al. Activation of a nonclassical NKT cell subset in a transgenic mouse model of hepatitis B virus infection. Immunity 2002;16:583-94.
30. Yang HI, Lu SN, Liaw YF, You SL, et al. Hepatitis B e antigen and the risk of hepatocellular carcinoma. N Engl J Med 2002;347:168-74.
31. Wong JB, Koff RS, Tine F, Pauker SG. Cost-effectiveness of interferon-alpha 2b treatment for hepatitis B e antigenpositive chronic hepatitis B. Ann Intern Med 1995;122(9):664–675.
32. Realdi G, Alberti A, Rugge M, Bortolotti F, et al. Seroconversion from hepatitis B e antigen to anti-HBe in chronic hepatitis B virus infection. Gastroenterology 1980;79:195-9.
33. Liaw YF, Chu CM, Su IJ, Huang MJ, et al. Clinical and histological events preceding hepatitis B antigen seroconversion in chronic type B hepatitis. Gastroenterology 1983;84:216-9.
34. Liaw YF, Chu CM, Huang MJ, Sheen IS, et al. Determinants for hepatitis B e antigen clearance in chronic type B hepatitis. Liver 1984;4:301-6.
35. Chu CI, Hussain M, Lok AS. Hepatitis B virus genotype B is associated with eatlier seroconversion compared with hepatitis B virus genotype C. Gastroenterology 2002;122:1756-62.
36. Lok AS. Replication of hepatitis B virus in Chinese patients with chronic hepatitis B virus infection [MD thesis]. Hong Kong: Univ. of Hong Kong, 1990.
37. Chu CM, Yeh CT, Lee CS, Sheen IS, et al. Precore sop mutant in HBeAg-positive patients with chronic hepatitis B: clinical characteristic and correlation with the course of HBeAg-to-anti-HBe seroconversion. J Clinical Microbiology 2002;40:16-21.
38. Karino Y, Toyota J, Sato T, Ohmura T, et al. Early mutation of precore (A1896) region prior to core promoter region mutation leads to decrease of HBV replication and remission of hepatic inflammation. Dig Dis Sci 2000;45:2207–13.
39. Yamaura T, Tanaka E, MatsumotoA, Rokuhara A, et al. A Case-Control Study for Early Prediction of Hepatitis B e Antigen Seroconversion by Hepatitis B Virus DNA Levels and Mutations in the Precore Region and Core Promoter. J Med Virol 2003;70:545–552.
40. Li JS, Tong SP, Wen YM, Vitvitski L, et al. Hepatitis B virus genotype A rarely circulates as an HBe-minus mutant: possible contribution of a single nucleotide in the precore region. J Virol 1993;67:5402-10.
41. Rodriguez-Frias F, Buti M, Jardi R, Cotrina M, et al. Hepatitis B virus infection: precore mutants and its relation to viral genotypes and core mutations. Hepatology 1995;22:1641-7.
42. Yeh SH, Tsai CY, Kao JH, Liu CJ, et al. Quantification and genotyping of hepatitis B virus in a single reaction by real-time PCR and melting curve analysis. J Hepatology 2004;41:659-66.
43. Noguchi A, Hayashi J, Najashima K, Horata M, et al. HBsAg subtypes among HBsAg carriers in Okinawa, Japan. Evidence of an important relationship in seroconversion from HBeAg to anti-HBe. J Infect 1994;28:141-150.
44. Hoofnagle JH, Dusheiko GM, Seeff LB, Jones EA, et al. Seroconversion from hepatitis B e antigen to antibody in chronic type B. Ann of Inter Med 1981;94:744-8.
45. Schulte-Frohlide E, Foster GR. Spontaneous seroconversion in chronic hepatitis B: role of mutations in the precore/core gene. Dig Dis Sci 1998;8:1714-8.
46. Kao JH, Chen PJ, Lai MY, Chen DS. Hepatitis B virus genotypes and spontaneous sepatitis B e antigen seroconversion in Taiwanese hepatitis B carriers. J Med Virol 2004;72:363–369.
47. Ou, J.-H. Molecular biology of hepatitis B virus e antigen. J Gastroenterol Hepatol 1997;12(Suppl.):S178–87.
48. Buckwold VE, Xu Z, Chen M, Yen TS, et al. Effects of a naturally occurred mutation in the hepatitis B virus basal core promoter on precore gene expression and viral replication. J Virol 1996;70:5845–5851.
49. Yuen MF, Sablon E, Yuan HJ, Hui CK, et al. Relationship between the development of precore and core promoter mutations and hepatitis B e antigen seroconversion in patients with chronic hepatitis B virus. J Infect Dis 2002;186:1335-8.
50. Fattovich G, M.D. Natural history and prognosis of hepatitis B. Semin of Liver Dis 2003;23:47-58.
51. Alter HJ, Seeff LR, Kaplan PM, McAuliffe VJ, et al. Type B hepatitis: the infectivity of blood positive for e antigen and DNA polymerase after accidental needlestick exposure. N Engl Med. 1976;295:909-13.
52. Karayiannis P. Hepatitis B virus: old, new and future approaches to antiviral treatment. J Antimicrobial Chemotherapy 2003; 51:761-85.
53. Lau GKK, Lai CL, Wu PC. The natural history of chronic hepatitis B infection. HKMJ 1997;3:283-8. | en |