HLA DRB1 Genotype, Human Papillomavirus, and Cervical Cancer in Taiwan
Date Issued
2004
Date
2004
Author(s)
Hung, Chiung-Fang
DOI
zh-TW
Abstract
Background: Infection with human papillomavirus (HPV) is the major risk factor for cervical cancer. HLA II molecules could present foreign antigens to T cells, then inducing a series of immune responses. The highly polymorphisms of HLA II genes may affect the persistent infection of HPV, further leading to the occurrences of cervical cancer. This study aimed to investigate the association of HLA DRB1 genetic polymorphisms and cervical cancer in HPV infection.
Methods: This study is a case-control study. During 1991 to 2003, we recruited 89 cervical cancer patients (including in situ and invasive cancer) from a linkage with National Cancer Registry, National Death Certification and National Cervical Neoplasia Registry in the large-scale community-based cervical neoplasia screening project of seven townships. We recruited 304 controls which matched by age, residential township and sampling time. HLA typing was done by polymerase chain reaction-based method, followed by sequence-specific oligonucletide probe hybridization. G test or Fisher’s exact test were used to examine the differences in the frequency distributions between cases and controls. Conditional and unconditional logistic regression models were used to assess the association between HLA-DRB1 genes and cervical cancer with odds ration (ORs) and 95% confidence interval (CIs).
Result: DRB1*1401 was found to be associated with HPV infection (OR, 4.4; 95% CI, 1.6-11.9). Compared HPV cases with controls, DRB1*0303 (OR, 7.4; 95%CI, 1.5-37.3) and DRB1*1101 (OR, 2.2; 95%CI, 1.3-3.6) were found to be associated with cervical cancer. DRB1*1101 were still found to be associated with cervical cancer after adjusting the effects of HPV infection (OR, 2.5; 95% CI. 1.1-6.0). Compared the high-risk HPV cases with controls, DRB1*1202 significantly decreased the risks of cervical cancer (OR, 0.2; 95% CI. 0.1-0.7). Compared HPV 16 relative type cases with controls, DRB1*1202 also significantly decreased the risks of cervical cancer (OR, 0.2; 95% CI. 0.1-0.7).
Subjects
子宮頸癌
人類疣瘤病毒
人類白血球抗原
human leukocyte antigen
human papillomavirus
cervical cancer
SDGs
Type
thesis
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