https://scholars.lib.ntu.edu.tw/handle/123456789/112248
標題: | POPULATION-BASED FAMILY CASE-CONTROL PROBAND STUDY ON FAMILIAL AGGREGATION OF METABOLIC SYNDROME: FINDING FROM TAIWANESE PEOPLE INVOLVED IN KEELUNG COMMUNITY-BASED INTEGRATED SCREENING (KCIS NO. 5) | 作者: | CHIU, YUEH-HSIA LIN, WEN-YUAN CHEN, YAO-DER CHEN, TONY, HSIU-HIS 陳秀熙 |
關鍵字: | metabolic syndrome;family case-control proband study;familial aggregation;environmental factors | 公開日期: | 2007 | 卷: | v.75 | 期: | n.3 | 起(迄)頁: | 348-356 | 來源出版物: | DIABETES RESEARCH AND CLINICAL PRACTICE | 摘要: | A population-based case-control proband study was undertaken to elucidate familial aggregation, independent environmental factors, and the interaction between them. A total of 7308 metabolic syndrome (MET-S) cases were identified from the Keelung community-based integrated screening programme between 1999 and 2002. The study has a case-control/family sampling design. A total of 1417 case probands were randomly selected from 3225 metabolic syndrome cases and the corresponding 2458 controls selected from 16, 519 subjects without metabolic syndrome by matching on sex, age ( 3 years) and place of residence. The generalized estimation equation model was used to estimate odds ratios and corresponding 95% confidence intervals. The risk for having metabolic syndrome among family members for cases versus control probands was 1.56-fold (1.29-1.89) after controlling for significant environmental factors. Higher risk of metabolic syndrome was found in parents than spouse. Low education against high education had 2.06-fold (1.36-3. 13) risk for metabolic syndrome. Betel quid chewing was positively associated with the risk of MET-S, with 1.99-fold (1.13-3.53) risk for 1-9 pieces and 1.76-fold (0.96-3.23) risk for > 10 pieces compared with non-chewer. Moderate and high intensity of non-occupational exercise led to 2 1.0% ( OR= 0.79 (0.63-0.98)) and 26.0% (OR= 0.74 (0.59-0.94)) reduction in the risk for metabolic syndrome, respectively. The frequent consumption of vegetable reduced 24.0% (OR = 0. 76 (0.62-0.92)) risk for MET-S. The frequent consumption of coffee was associated the increased risk for metabolic syndrome (OR = 1.32 (1.07-1.64)). The present study confirmed the risk of metabolic syndrome not only has the tendency towards familial aggregation but is affected by independent effect of environmental or individual correlates . (c) 2006 Elsevier Ireland Ltd. All rights reserved. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/81669 |
顯示於: | 流行病學與預防醫學研究所 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。