https://scholars.lib.ntu.edu.tw/handle/123456789/112290
標題: | SEGREGATION ANALYSIS OF APOLIPOPROTEIN A1 LEVELS IN FAMILIES OF ADOLESCENTS: A COMMUNITY-BASED STUDY IN TAIWAN | 作者: | CHIEN, KUO-LIONG 陳為堅 |
關鍵字: | HIGH-DENSITY-LIPOPROTEIN;ATHEROSCLEROTIC RISK-FACTORS;CORONARY-ARTERY-DISEASE;CLINICS PROGRAM FAMILY;GENETIC- ANALYSIS;CHOLESTEROL LEVELS | 公開日期: | 2006 | 卷: | v.7 | 起(迄)頁: | AR-7 | 來源出版物: | BMC GENETICS | 摘要: | Background: Apolipoprotein (Apo) AI is a protective factor for cardiovascular events. This study aimed to perform complex segregation analyses of Apo AI levels in families of adolescents systematically ascertained from the junior high school students in a rural community. Both siblings and parents of the adolescent probands were recruited for the study. Apo AI concentrations were measured by turbidimetric immunoassay methods. After adjustment for gender, age, body mass index, smoking and drinking status, residual values of Apo AI were subjected to subsequent analyses. Results: Significant mother-father and parent-offspring correlations were found. Commingling analyses indicated that a four- component distribution model was needed to account for the Apo AI variation. Segregation analysis using regressive models revealed that the best-fit model of Apo AI was a model of environmental effect plus familial correlation ( heritability = 23.9%), in which a significant mother-father correlation existed. Models containing major gene effect could be rejected. Conclusion: These results suggest that variations of Apo AI levels in the normal range, especially during adolescence, are likely to be influenced by multiple factors without significant contribution from major genes. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/81704 |
顯示於: | 流行病學與預防醫學研究所 |
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