DC 欄位 | 值 | 語言 |
dc.contributor | 于明暉 | zh-TW |
dc.contributor | Yu, Ming-Whei | en |
dc.contributor | 臺灣大學:流行病學研究所 | zh-TW |
dc.contributor.author | 王雅蕙 | zh-TW |
dc.contributor.author | Wang, Ya-Hui | en |
dc.creator | 王雅蕙 | zh-TW |
dc.creator | Wang, Ya-Hui | en |
dc.date | 2008 | en |
dc.date.accessioned | 2010-05-05T10:55:47Z | - |
dc.date.accessioned | 2018-06-29T17:53:26Z | - |
dc.date.available | 2010-05-05T10:55:47Z | - |
dc.date.available | 2018-06-29T17:53:26Z | - |
dc.date.issued | 2008 | - |
dc.identifier.other | U0001-2007200814092900 | en |
dc.identifier.uri | http://ntur.lib.ntu.edu.tw//handle/246246/180689 | - |
dc.description.abstract | Background: In hepatocellular carcinomas (HCCs), frequent allelic loss on chromosome 1p has been reported. Using linkage analysis on multiplex families, a HCC-susceptibility locus has been mapped to a broad region of chromosome 1p32.2-36.1. aterials and Methods: Here we have used a positional candidate gene strategy, based on association mapping with single nucleotide polymorphisms (SNPs) on 19 candidate genes within the linked region among 240 families with HCC, followed by a case-control analysis involving an independent set of 855 cases and 875 controls. Significance of the association was assessed by the false-discovery rate q value, which accounts for multiple testing. esults: In the family sample, we observed a significant association between HCC and five single-nucleotide polymorphisms (SNPs) in a haplotype block by using the pedigree disequilibrium test. SNP 13, located in the 3’ untranslated region (UTR) of the retinoblastoma binding protein 4 (RBBP4) gene, showed the strongest evidence (nominal P=0.0047; empirical P=0.0025; q=0.0188). Further case-control analysis confirmed the genetic association between SNP13 and HCC, and identified additional two SNPs in the same haplotype block. The C allele (minor allele) of SNP13 conferred an increased risk for HCC (odds ratio [95% confidence interval]: 1.36 [1.11-1.65] for heterozygotes; 1.29 [0.90-1.84] for homozygotes ). SNP13 and two neighboring SNPs fell on a common haplotype (‘C-A-C’ at SNP13-SNP14-SNP15), which was also associated with an increase risk of HCC.onclusion: NP13 was consistently associated with HCC in both family and case-control sample. | en |
dc.description.tableofcontents | Introduction ………………………………………………………1aterials and Methods……………………………………………4esults………………………………………………………………9iscussion…………………………………………………………13eferences…………………………………………………………16able 1 ……………………………………………………………28able 2 ……………………………………………………………30able 3 ……………………………………………………………31able 4 ……………………………………………………………32able 5 ……………………………………………………………33able 6 ……………………………………………………………34able 7 ……………………………………………………………35able 8 ……………………………………………………………36able 9 ……………………………………………………………37igure 1……………………………………………………………38igure 2……………………………………………………………39igure 3……………………………………………………………40 | en |
dc.format | application/pdf | en |
dc.format.extent | 453584 bytes | - |
dc.format.mimetype | application/pdf | - |
dc.language | en | en |
dc.language.iso | en_US | - |
dc.subject | 候選基因策略 | zh-TW |
dc.subject | 家族研究 | zh-TW |
dc.subject | 病例對照 | zh-TW |
dc.subject | 關連性分析 | zh-TW |
dc.subject | 肝癌易感受基因 | zh-TW |
dc.subject | Positional candidate gene approach | en |
dc.subject | family study | en |
dc.subject | case-control study | en |
dc.subject | association study | en |
dc.subject | HCC susceptibility gene | en |
dc.title | 染色體1p32.2-36.1區域肝癌易感受基因連鎖高峰之定位:候選基因策略 | zh-TW |
dc.title | Identification of Hepatocellular Carcinoma Susceptibility Gene by Peakwide Mapping on Chromosome 1p32.2-36.1: pplication of Positional Candidate Gene Approach | en |
dc.type | thesis | en |
dc.identifier.uri.fulltext | http://ntur.lib.ntu.edu.tw/bitstream/246246/180689/1/ntu-97-R95842015-1.pdf | - |
item.languageiso639-1 | en_US | - |
item.cerifentitytype | Publications | - |
item.openairetype | thesis | - |
item.fulltext | with fulltext | - |
item.grantfulltext | open | - |
item.openairecristype | http://purl.org/coar/resource_type/c_46ec | - |
顯示於: | 流行病學與預防醫學研究所
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