DC 欄位 | 值 | 語言 |
dc.contributor.author | 陳建仁 | zh_TW |
dc.creator | 陳建仁 | zh_TW |
dc.date | 2005-07-31 | zh_TW |
dc.date.accessioned | 2006-07-25T06:16:18Z | en |
dc.date.accessioned | 2018-06-29T17:53:39Z | - |
dc.date.available | 2006-07-25T06:16:18Z | en |
dc.date.available | 2018-06-29T17:53:39Z | - |
dc.date.issued | 2005-07-31 | - |
dc.identifier | 932320B002011 | en |
dc.identifier.uri | http://ntur.lib.ntu.edu.tw//handle/246246/4704 | - |
dc.description.abstract | 子宮頸癌是台灣女性首位好發癌症,其年齡標準化發生率為每十萬人年22.1 人,相
較於已開發國家的平均發生率11.2 人高出甚多。目前證據顯示主要危險因子為持續感染
高危險型人類疣瘤病毒(human papillomavirus, HPV)。但是大多數的研究均屬於橫斷性病
例對照研究,唯有透過長期追蹤研究才能釐清HPV 與子宮頸鱗狀上皮內病變(squamous
intraepithelial lesion, SIL)的因果時序性。為探討人類疣瘤病毒感染與生殖道披衣菌感染
對於誘發子宮頸癌的所扮演的角色及危險因子間的交互作用,本計畫採巢疊式病例對照
研究設計,婦女研究世代源於1991-1992 年在台灣七個鄉鎮市社區中邀請30 至64 歲婦
女自願參加子宮頸癌篩檢計畫,收案時採集子宮頸抹片進行SIL 之篩檢,並以陰道鏡輔
助病理切片予以確診。相關危險因子係透過結構式問卷進行標準化訪視獲得。每名研究
對象均以真空採血器及拋棄式針頭採取血液樣本,並以Virapap 採取子宮頸細胞。續以
全國癌症登記、子宮頸抹片檢查登記與死亡登記檔進行資料連鎖,追蹤該研究世代的新
診斷子宮頸癌病例。追蹤至2000 年共計114 名病例,並依病例的受檢年齡、居住地區
及受檢時間等條件進行配對,共獲得519 名對照組個案。取出保存於低溫冷凍櫃中該研
究個案受檢時所採集之血清/血漿進行HPV6, 16, 18 等型抗體與披衣菌抗體檢測,並以子
宮頸細胞進行HPV DNA 檢驗。結果顯示HPV16 型抗體陽性與子宮頸癌有著高度相關,
其危險勝算比為6.3 倍(95%信賴區間: 3.5-11.6)並達統計顯著差異。披衣菌感染與子宮頸
癌的相關僅限於新發病例,其危險勝算比達2.94 (95%信賴區間:1.17-7.42)。進一步分析
顯示同時感染HPV6 及HPV16 與子宮頸癌的相關,呈現拮抗之交互作用,其相差危險
性為- 4.68 (95%信賴區間: -10.63 to 1.27)],同時感染HPV16 及HPV18 亦呈現類似的
趨勢其相差危險性為-3.27 (95%信賴區間: -7.71-1.18)。本研究結果發現感染高危險性
HPV16 型與子宮頸癌之發生有高度相關,此外同時感染不同型別HPV 或感染披衣菌者
可能降低其致癌的風險。 | zh_TW |
dc.description.abstract | Cervical cancer is the most common cancer among women in Taiwan with an age
standardized incidence rate of 22.1 per 100,000 person-years compared to an average of 11.2
in developed countries. It is well established that the major cause of cervical cancer is
persistent infection with oncogenic genital human papillomavirus (HPV). To investigate the
possible role of interaction between human papillomavirus (HPV) types and past Chlamydia
trachomatis exposure in cervical carcinogenesis in a population with low sexual risk-taking
behavior, we performed a nested case-control study of invasive and in situ cervical cancer
within a community-based cohort of 13,595 Taiwanese women assembled in 1991. During a 9
year follow-up period (1991-2000) incident cases were identified through linkage with
nationwide cancer registry. Prevalent cases identified at the baseline cervical examination
were also included in the study. Baseline serum or plasma from 114 cases and 519 controls
matched for sex, age, area of residence, type of sample and date of enrolment were analyzed
for antibodies against HPV types 6, 16 and 18 and against C. trachomatis. HPV-16
seropositivity was strongly associated with cervical cancer OR= 6.33 (95% CI 3.45-11.62).
C. trachomatis was overall not associated with cervical cancer, but was associated with
cervical cancer in analyses restricted to incident cases of cancer OR:2.94 (95% CI
1.17-7.42)or to cases that had serum samples taken OR:3.13 (95% CI 1.16-8.47). We found
a tendency of antagonistic interaction between HPV-6 and -16 [Relative Excess Risk due to
Interaction (RERI):- 4.68 (95% CI –10.63 to 1.27)] and between HPV-16 and -18 [RERI:-3.27
(95% CI -7.71-1.18)]. Our results suggest that different HPV types might interfere in cervical
carcinogenesis, that C. trachomatis associates with cervical cancer in prospective studies and
support the notion that HPV-16 seropositivity is strongly associated with cervical cancer risk
in low sexual risk-taking populations. | en |
dc.format | application/pdf | en |
dc.format.extent | 254132 bytes | en |
dc.format.mimetype | application/pdf | en |
dc.language | zh_TW | zh_TW |
dc.language.iso | zh_TW | zh_TW |
dc.publisher | 臺北市:國立臺灣大學公共衛生學院流行病學研究所 | zh_TW |
dc.rights | 國立臺灣大學公共衛生學院流行病學研究所 | zh_TW |
dc.subject.classification | [SDGs]SDG3 | - |
dc.title | 人類疣瘤病毒與子宮頸癌變之巢疊病例對照研究(3/3) | zh_TW |
dc.type | report | en |
dc.identifier.uri.fulltext | http://ntur.lib.ntu.edu.tw/bitstream/246246/4704/1/932320B002011.pdf | - |
dc.coverage | 計畫年度:93;起迄日期:2004-08-01/2005-07-31 | zh_TW |
item.openairecristype | http://purl.org/coar/resource_type/c_93fc | - |
item.openairetype | report | - |
item.languageiso639-1 | zh_TW | - |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.fulltext | with fulltext | - |
顯示於: | 流行病學與預防醫學研究所
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