https://scholars.lib.ntu.edu.tw/handle/123456789/112448
標題: | CONCORDANCE OF POSITIVE AND NEGATIVE SYMPTOMS IN COAFFECTED SIB-PAIRS WITH SCHIZOPHRENIA. | 作者: | CHEN, WEI-JANE HWU, HAI-GWO 陳為堅 |
關鍵字: | positive symptom;negative symptom;schizophrenia;sib-pair | 公開日期: | 1997 | 卷: | 74 | 期: | 1 | 起(迄)頁: | 1-6 | 來源出版物: | American Journal of Medical Genetics Part B: Neuropsychiatric Genetics | 摘要: | Positive and negative symptom (NGS) dimensions were examined for their concordance in 46 coaffected schizophrenic sib- pairs. Results showed that the symptom dimensions of negative symptoms (NGS), delusion- hallucination(DHS), and thought disorganization (TDS) could be formulated. Discrete genetic endowment of these three symptom dimensions was not found as shown by the low concordance in sib pair analysis ( kappa = 0.20-0.30). Thirty-seven pairs (80.4%) and 21 pairs (45.7%) had liability, defined by the presence of NGS in any one member of the coaffected sib-pairs, of NGS of "any degree", and of "severe degree" in 46 sib-pairs, respectively. Both groups had high prevalence (59.1-81.0%) of positive symptoms. Another 9 (19.6%) and 25 (54.3%) pairs had no liability of NGS of "any degree" or of "severe degree" out of 46 sib- pairs, respectively. These two groups had high concordance ( kappa = 0.45-1.00) of TDS or DHS between coaffected sib- pairs. Based on the results, it is hypothesized that schizophrenia, as defined by DSM-III-R, may consist of two subtypes: one has liability of NGS and a high prevalence of positive symptoms, while the other has only positive symptoms. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/81837 |
顯示於: | 流行病學與預防醫學研究所 |
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