|Title:||POLYMORPHIC CATECHOL-O- METHYLTRANSFERASE GENE, DURATION OF ESTROGEN EXPOSURE, AND BREAST CANCER RISK: A NESTED CASE–CONTROL STUDY IN TAIWAN||Authors:||CHOU, YU-CHING
|Keywords:||Breast cancer risk;COMT genotype;Estrogen exposure;Education;First full-term pregnancy;Genomic DNA||Issue Date:||2005||Journal Volume:||v.29||Journal Issue:||n.5||Start page/Pages:||427-432||Source:||CANCER DETECTION AND PREVENTION||Abstract:||
Background: Polymorphic catechol-O-methyltransferase (COMT) catalyzes the O-methylation of catechol estrogens, which are hypothesized to participate in estrogen-induced carcinogenesis. Methods: We examined 87 cases and 341 population controls in Taiwan to determine the association between the functional genetic Val158Met polymorphism in membrane-bound form of COMT gene and female breast cancer risk. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated by conditional logistic regression. Results: There was no overall association between COMT genotype and individual susceptibility to breast cancer. However, COMT-L variant genotypes appear to pose increased risk of breast cancer in women with greater duration from menarche to first full-term pregnancy (>8 years) (OR, 2.67; 95% CI, 1.00–7. 36). Conclusions: This study based on limited sample sizes suggests that there may be no overall association of COMT genotype with breast cancer, but the COMT-L allele could pose enhanced risk of breast cancer in the presence of relevant environmental exposures, as most low penetrance gene are expected to act through gene–environment interactions.
|Appears in Collections:||流行病學與預防醫學研究所|
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