https://scholars.lib.ntu.edu.tw/handle/123456789/112450
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor | 流行病學研究所;Graduate Institute of Epidemiology | en |
dc.contributor.author | CHEN, CHIEN-JEN | en |
dc.creator | CHEN, CHIEN-JEN | en |
dc.creator | 陳建仁 | zh-tw |
dc.date | 2002 | en |
dc.date.accessioned | 2008-09-18T01:42:53Z | - |
dc.date.accessioned | 2018-06-29T17:54:13Z | - |
dc.date.available | 2008-09-18T01:42:53Z | - |
dc.date.available | 2018-06-29T17:54:13Z | - |
dc.date.issued | 2002 | - |
dc.identifier.uri | http://ntur.lib.ntu.edu.tw//handle/246246/81901 | - |
dc.description.abstract | Dietary exposure to aflatoxins is one of the major risk factors for hepatocellular carcinoma. Individual susceptibility to aflatoxin-induced hepatocarcinogenesis may be modulated by both genetic and environmental factors affecting metabolism, A cross-sectional study was performed to evaluate determinants of the formation of aflatoxin covalently bound to albumin (AFB(1)-albumin adducts). A total of 474 subjects who were free of liver cancer and cirrhosis and were initially selected as controls for previous case-control studies of aflatoxin-induced hepatocarcinogenesis in Taiwan, were employed in this study. Aflatoxin-albumin adducts were determined by competitive enzyme-linked immunosorbent assay, hepatitis B surface antigen and antibodies to hepatitis C virus by enzyme immunoassay, as well as genotypes of glutathione S- transferase M1-1 and T1-1 by polymerase chain reaction. The detection rate of AFB(1)-albumin adducts was significantly higher in males (42.5%) than in females (21.6%) ( multivariate-adjusted odds ratio=2.6, 95% confidence interval = 1.4-5.0). The formation of detectable albumin adducts was moderately higher in hepatitis B surface antigen carriers (42.8%) than in non-carriers (36.6%) (multivariate -adjusted odds ratio = 1.4, 95% confidence interval = 1.0-2 . 1). In addition, the detection rate of AFB(1)-albumin adducts tended to increase with the increasing number of null genotypes of glutathione S-tronsferose M1-1 and glutothione S-transferase T1-1. In conclusion, this cross- sectional study has assessed the relative contributions of environmental exposure and host susceptibility factors in the formation of AFB(1)-albumin adducts in a well characterised Chinese adult population. This study further emphasises the necessity to reduce aflatoxin exposure in people living in an area endemic for chronic hepatitis B virus infection. (C) 2002 Cancer Research UK. | en |
dc.language | en-us | en |
dc.language.iso | en_US | - |
dc.relation | BRITISH JOURNAL OF CANCER v.87 n.9 pp.966-970 | en |
dc.relation.ispartof | BRITISH JOURNAL OF CANCER | - |
dc.subject | aflatoxin-albumin adducts | en |
dc.subject | glutathione S-transferase MI-I | en |
dc.subject | glutathione S-transferase TI-I | en |
dc.subject | hepatitis B surface antigen | en |
dc.subject | HEPATITIS-B VIRUS | en |
dc.subject | S-TRANSFERASE M1 | en |
dc.subject.classification | [SDGs]SDG3 | - |
dc.title | DETERMINANTS OF FORMATION OF AFLATOXIN-ALBUMIN ADDUCTS: A SEVEN- TOWNSHIP STUDY IN TAIWAN | en |
dc.type | journal article | en |
dc.relation.pages | 966-970 | - |
dc.relation.journalvolume | v.87 | - |
dc.relation.journalissue | n.9 | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.languageiso639-1 | en_US | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
顯示於: | 流行病學與預防醫學研究所 |
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