https://scholars.lib.ntu.edu.tw/handle/123456789/112534
標題: | DATA-DREDGING GENE-DOSE ANALYSES IN ASSOCIATION STUDIES: BIASES AND THEIR CORRECTIONS | 作者: | LEE, WEN-CHUNG | 公開日期: | 2005 | 卷: | v.14 | 期: | n.12 | 起(迄)頁: | 3004-3006 | 來源出版物: | CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION | 摘要: | To examine the joint effect of multiple loci on disease risk , many case-control association studies used "gene-dose analyses." However, some researchers defined high-risk genotypes (or alleles) as those that have higher genotypic ( allelic) frequencies in the case group compared with the control group in the study. This will lead to the total number of the "high-risk" genotypes (alleles) tending to be higher for the cases than for the controls as well, even if none of the studied loci were related to the disease. Monte- Carlo simulations done in this study showed that such a " data-dredging" gene-dose analysis could produce grossly biased results. A permutation correction method was proposed which could correct the biases very effectively. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/82049 |
顯示於: | 流行病學與預防醫學研究所 |
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