https://scholars.lib.ntu.edu.tw/handle/123456789/112540
標題: | SECULAR TRENDS AND GEOGRAPHIC VARIATIONS OF HEPATITIS B VIRUS AND HEPATITIS C VIRUS-ASSOCIATED HEPATOCELLULAR CARCINOMA IN TAIWAN | 作者: | LU, SHENG-NAN SU, WEI-WEN YANG, SHENG-SHUN CHANG, TING-TSUNG CHENG, KEN-SHENG WU, JAW-CHING LIN, HANS, HSIEN-HONG WU, SHUN-SHENG LEE, CHUAN-MO CHANGCHIEN, CHI-SIN CHEN, CHIEN-JEN SHEU, JIN-CHUAN CHEN, DING-SHINN |
關鍵字: | hepatocellular carcinoma;hepatitis B virus;hepatitis C virus;secular trend;geographic variation;Taiwan | 公開日期: | 2006 | 卷: | v.119 | 期: | n.8 | 起(迄)頁: | 1946-1952 | 來源出版物: | INTERNATIONAL JOURNAL OF CANCER | 摘要: | Etiological variations in hepatocellular carcinoma (HCC) exist across different geographic areas. To gain better control of HCC, we retrospectively studied the secular trends and geographic variations in hepatitis B virus (HBV)- related and hepatitis C virus (HCV)-related HCCs in Taiwan. A total of 18,423 HCC cases enrolled in 8 medical centers from 1981 to 2001 were reviewed. Overall, 67% of male HCC in Taiwan was related to HBV infection whereas 55.2% of female HCC in Taiwan was related to HCV infection. The mean age of patients with HBV-related HCC was 53.2 +/- 13.6 years, while the mean age of patients with HCV-related HCC was 65.1 +/- 9.1 years (p < 0.001). The male/female ratio was 6.4 for HBV-related HCC, while it was 1.7 for the HCV-related HCC ( p < 0.001). The percentage of HBV-related HCC progressively decreased from 81.5 to 66.2% in males, and from 66.7 to 41. 4% in females over the study period. Our study demonstrates that the percentage of HBV-related HCC has progressively decreased over the last 20 years. The relative decrease in HBV-related HCC was not due to a decrease in HBV-related HCC death. Instead, it was caused by an increase in HCV-related HCC. Prevention of new HCV infection and the treatment of chronic hepatitis C should be the primary goals, which will result in better control of HCC in the future, even in an HBV-endemic area like Taiwan.( c) 2006 Wiley-Liss, Inc. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/82059 |
顯示於: | 流行病學與預防醫學研究所 |
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