https://scholars.lib.ntu.edu.tw/handle/123456789/112646
標題: | GENETIC VARIANTS OF MYELOPEROXIDASE AND CATECHOL-O-METHYLTRANSFERASE AND BREAST CANCER RISK | 作者: | Lin, S-C Chou, Y-C Wu, M-H Wu, C-C Lin, W-Y Yu, C-P Yu, J-C You, S-L Chen, C-J Sun, C-A |
關鍵字: | breast cancer;catechol-O-methyltransferase;polymorphisms;myeloperoxidase;oestrogen exposure | 公開日期: | 2005 | 卷: | v.14 | 期: | n.3 | 起(迄)頁: | 257-261 | 來源出版物: | EUROPEAN JOURNAL OF CANCER PREVENTION | 摘要: | This nested case-control study evaluated the role of polymorphisms in the myeloperoxidase (MPO) and catechol-O- methyltransferase (COMT) genes that modulate oxidative stress in breast cancer risk in a Chinese population. Our results demonstrate that the MPO A/A genotype was associated with a reduced risk of breast cancer (odds ratio (OR) 0.64; 95% confidence interval (CI) 0.11-3.76), whereas there was no overall association of COMT genotype with breast cancer. Of note, an elevated breast cancer risk associated with the increasing numbers of high-risk genotypes of MPO and COMT genes was observed in women with a longer duration between menarche and first full-term pregnancy.(C) 2005 Lippincott Williams & Wilkins, Inc. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/82065 |
顯示於: | 流行病學與預防醫學研究所 |
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