https://scholars.lib.ntu.edu.tw/handle/123456789/112683
標題: | A TWO-SAMPLE COMPARISON FOR MULTIPLE ORDERED EVENT DATA | 作者: | CHANG, SHU-HUI | 關鍵字: | accelerated failure time model;correlated failure time;informative censoring;log-rank statistic | 公開日期: | 2000 | 卷: | v.56 | 期: | n.1 | 起(迄)頁: | 183-189 | 來源出版物: | BIOMETRICS | 摘要: | A longitudinal study is conducted tu compare the process of a particular disease between two groups. The process of the disease is monitored according to which of several ordered events occur. In the paper, the sojourn time between two successive events is considered as the outcome of interest. The group effects on the sojourn times of the multiple events are parameterized by scale changes in a semiparametric accelerated failure time model where the dependence structure among the multivariate sojourn times is unspecified. Suppose that the sojourn times are subject to dependent censoring and the censoring times are observed for all subjects. A log-rank-type estimating approach by rescaling the sojourn times and the dependent censoring times into the same distribution is constructed to estimate the group effects and the corresponding estimators are consistent and asymptotically normal. Without the dependent censoring, the independent censoring times in general are not available for the uncensored data. In order to complete the censoring information, pseudo-censoring times are generated from the corresponding nonparametrically estimated survival function in each group, and we can still obtained unbiased estimating functions for the group effects. A real application and a simulation study are conducted to illustrate the proposed methods. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/92359 |
顯示於: | 流行病學與預防醫學研究所 |
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