https://scholars.lib.ntu.edu.tw/handle/123456789/112690
標題: | GENETIC POLYMORPHISMS OF GLUTATHIONE S-TRANSFERASES M1 AND TI ASSOCIATED WITH SUSCEPTIBILITY TO AFLATOXIN- RELATED HEPATOCARCINOGENESIS AMONG CHRONIC HEPATITIS B CARRIERS: A NESTED CASE-CONTROL STUDY IN TAIWAN | 作者: | SUN, CHIEN-AN WANG, LI-YU CHEN, CHIEN-JEN LU, SHENG-NAN YOU, SAN-LIN WU, DER-MI |
關鍵字: | LUNG-CANCER RISK;HEPATOCELLULAR-CARCINOMA;LIVER-CANCER;T1 POLYMORPHISMS;THETA GSTT1;B-1 | 公開日期: | 2001 | 卷: | v.22 | 期: | n.8 | 起(迄)頁: | 1289-1294 | 來源出版物: | CARCINOGENESIS | 摘要: | This study was conducted to investigate the modifying effect of glutathione S-transferase (GST) M1 and T1 polymorphisms on aflatoxin-induced hepatocarcinogenesis among chronic hepatitis B virus surface antigen (HBsAg) carriers. A total of 79 HBsAg-positive cases of hepatocellular carcinoma (HCC) diagnosed between 1991 and 1997 were identified and individually matched to one or two HBsAg-positive controls on age, gender, residence and date of recruitment from the same cancer screening cohort in Taiwan. Blood samples were tested for hepatitis B and C viral markers by enzyme immunoassay and for aflatoxin B-1 (AFB(1))-albumin adducts by competitive enzyme-linked immunosorbent assay. GSTM1 and GSTT1 genotypes were determined by PCR. There was a statistically significant relationship between detectable levels of AFB(1)-albumin adducts in serum and risk of HCC among chronic HBsAg carriers, with an adjusted odds ratio ( OR) of 2.0 [95% confidence interval (CI) 1.1-3.7]. In addition, the effect of aflatoxin exposure on HCC risk was more pronounced among chronic HBsAg carriers with the GSTT1 null genotype (OR 3.7, 95% Cl 1.5-9.3) than those who were nonnull (OR 0.9, 95% CI 0.3-2.4). The interaction between serum AFB(1)-albumin adduct level and GSTT1 genotype was statistically significant (P = 0.03). For GSTM1 the effect of aflatoxin exposure on HCC risk in those with the null genotype was also greater (adjusted OR 2.8, 95% CI 1.0-7.8) than in those with the gene present (adjusted OR 1.8, 95% CI 0.8-4.5), but the difference was not significant (P = 0.91) . Notably, when the interaction between aflatoxin exposure and GSTT1 genotype was considered, aflatoxin exposure by itself was not a significant determinant of HCC risk among chronic HBsAg carriers. These results demonstrate the importance of gene-environment interactions in the multifactorial development of HCC. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/83482 |
顯示於: | 流行病學與預防醫學研究所 |
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