https://scholars.lib.ntu.edu.tw/handle/123456789/112706
標題: | VARIABILITY IN AFLATOXIN-ALBUMIN ADDUCT LEVELS AND EFFECTS OF HEPATITIS B AND C VIRUS INFECTION AND GLUTATHIONE S-TRANSFERASE M1 AND T1 GENOTYPE | 作者: | WANG, LI-YU CHEN, CHIEN-JEN |
關鍵字: | aflatoxin-albumin adducts;biomarkers;intraindividual variability;liver cancer;molecular epidemiology | 公開日期: | 2001 | 卷: | v.109 | 期: | n.8 | 起(迄)頁: | 833-837 | 來源出版物: | ENVIRONMENTAL HEALTH PERSPECTIVES | 摘要: | Exposure to aflatoxin B-1 (AFB(1)), an important cofactor in the etiology of hepatocellular carcinoma in Taiwan, is influenced by dietary and other factors. The present study examined the intraindividual variability in AFB(1)-albumin adducts, the most reliable long-term biomarker of AFB(1) exposure, and whether the baseline or follow-up adduct levels and the intraindividual variability in adduct levels are modified by endogenous and environmental factors. The study measured AFB(1)-albumin adduct levels among 264 healthy male residents of three townships (Hu-Hsi, Ma-Kung, and Pai-Hsa) of Penghu Islets, Taiwan, at two different time points with a median interval of 1.68 years (range 1.00-3. 17 years). There was a generalized reduction in the adduct levels, with the median values being 22.1 pmol/mg (range 5.0 -355.8 pmol/mg) at time 1 and 14.3 pmol/mg (range 5.0-205.2 pmol/mg) at time 2. This intraindividual variability in adduct levels was inversely associated with the age of subjects and the tirne interval between the two blood draws. The variability in adduct levels was lower among subjects in Hu-Hsi and Pai-Hsa townships as compared to those in Ma- Kung. No significant association was observed for the intraindividual variability in AFB(1)-albumin adducts with regard to the season when blood was drawn. There was also no significant association between intraindividual variability and hepatitis B surface antigen, anti-hepatitis C virus ( anti-HCV, glutathione S-transferase (GST) M1, or GSTT1 status. In conclusion, we found substantial intraindividual variability in the AFB(1) exposure (as determined by AFB(1)- albumin adducts) in Taiwan, which was probably more likely related to dietary or other environmental influences rather than to endogenous factors (e.g., hepatitis B/C viral infection or GST M1/T1 genetic status). |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/83513 |
顯示於: | 流行病學與預防醫學研究所 |
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