https://scholars.lib.ntu.edu.tw/handle/123456789/112708
Title: | IMMUNE STATUS IN PRESCHOOL CHILDREN BORN AFTER MASS HEPATITIS B VACCINATION PROGRAM IN TAIWAN | Authors: | LIN, DING-BANG LEE, YAO-LING CHANG LAI, SHENG-PING CHEN, CHIEN-JEN |
Keywords: | HBV seroepidemiology;preschool children;Taiwan | Issue Date: | 1998 | Journal Volume: | v.16 | Journal Issue: | n.17 | Start page/Pages: | 1683-1687 | Source: | VACCINE | Abstract: | A mass hepatitis B vaccination program began in Taiwan in 1984. In order to determine the immune status of hepatitis B virus (HBV) infection among preschool children, a total of 25 kindergartens in 20 townships and metropolitan precincts in central Taiwan were randomly selected through stratified sampling. Serum specimens of 2130 healthy preschool children aged 2-6 years old were screened for the HBV markers and liver function in 1996, HBV surface antigen (HBsAg), antibody against HBsAg (anti-HBs) and antibody against HBV core antigen (anti-HBc) were tested by reverse passive hemagglutination (RPHA), enzyme immunoassay (EIA) and radioimmunoassay (RIA) using commercial kits. HBV vaccination rate of the preschool children was 98%, and complete vaccination rate (three or four doses of HBV vaccine) was 94%, The HBsAg seropositive rate was 4.5% among incomplete vaccinees and 1.3% among complete vaccinees. The anti-HBs was detectable in 1637 of 2000 complete vaccinees( 81.9%) and in 53 of 88 incomplete vaccinees (60.2%), The overall prevalence rate of anti-HBc was 2.4% (52 of 2130). The older the age, the lower the anti-HBs seropositive rate. The anti-HBs seropositive rates for complete vaccinees were 100% at 2 years old and 75% at 6 years old. There were no significant differences in HBsAg-seropositive rates and anti -HBs-seropositive rates among different residential areas or ethnic groups. There were three children who were seropositive on HBsAg, anti-HBs and anti-HBc, whether they were infected by the vaccine-induced escape mutant of HBV deserves scrutiny. (C) 1998 Elsevier Science Ltd. All rights reserved. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/83908 |
Appears in Collections: | 流行病學與預防醫學研究所 |
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