https://scholars.lib.ntu.edu.tw/handle/123456789/112714
標題: | ASSOCIATION OF AFLATOXIN B-1-ALBUMIN ADDUCT LEVELS WITH HEPATITIS B SURFACE ANTIGEN STATUS AMONG ADOLESCENTS IN TAIWAN | 作者: | CHEN, SHU-YUAN CHEN, CHIEN-JEN CHOU, SHAN-RU HSIEH, LING-LING |
關鍵字: | REPUBLIC-OF-CHINA;HEPATOCELLULAR-CARCINOMA;VIRUS-INFECTION;CHEMICAL HEPATOCARCINOGENS;METABOLIC-ACTIVATION;TRANSGENIC MICE | 公開日期: | 2001 | 卷: | v.10 | 期: | n.11 | 起(迄)頁: | 1223-1226 | 來源出版物: | CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION | 摘要: | Chronic hepatitis B virus (HBV) infection and aflatoxin B-1( AFB(1)) exposure interact synergetically to induce hepatocellular carcinoma. One suggested mechanism for this interaction is the enhanced activation of AFB(1) in chronically HBV-infected individuals. Whereas no associations between chronic HBV infection and AFB(1)- albumin adducts were observed in several studies in adults, hepatitis B surface antigen (HbsAg)-positive children were found to have elevated adducts in Gambia. To assess the association between chronic HBV infection and AFB(1)-albumin adduct level in Taiwan, 200 junior high school adolescents from 20 townships were assayed for HBsAg and AFB(1)-albumin adducts. The mean AFB(1)-albumin adduct level was higher in HBsAg-positive compared with HBsAg-negative subjects. The association between HBsAg status and AFB(1)-albumin adducts remained after multivariate adjustment. This finding additionally supports the synergetic interaction between HBV and AFB(1), but the mechanism remains to be elucidated. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/84092 |
顯示於: | 流行病學與預防醫學研究所 |
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