https://scholars.lib.ntu.edu.tw/handle/123456789/113238
Title: | Impact of quarantine on the 2003 SARS outbreak: A retrospective modeling study | Authors: | Hsieh, Ying-Hen King, Chwan-Chuan Chen, Cathy W.S Ho, Mei-Shang Hsu, Sze-Bi Wu, Yi-Chun |
Keywords: | Discrete time compartmental model; Emerging infectious diseases; Intervention; Quarantine; SARS; Taiwan | Issue Date: | 2007 | Journal Volume: | v.244 | Journal Issue: | n.4 | Start page/Pages: | 729-736 | Source: | Journal of Theoretical Biology | Abstract: | During the 2003 Severe Acute Respiratory Syndrome (SARS) outbreak, traditional intervention measures such as quarantine and border control were found to be useful in containing the outbreak. We used laboratory verified SARS case data and the detailed quarantine data in Taiwan, where over 150,000 people were quarantined during the 2003 outbreak, to formulate a mathematical model which incorporates Level A quarantine (of potentially exposed contacts of suspected SARS patients) and Level B quarantine (of travelers arriving at borders from SARS affected areas) implemented in Taiwan during the outbreak. We obtain the average case fatality ratio and the daily quarantine rate for the Taiwan outbreak. Model simulations is utilized to show that Level A quarantine prevented approximately 461 additional SARS cases and 62 additional deaths, while the effect of Level B quarantine was comparatively minor, yielding only around 5% reduction of cases and deaths. The combined impact of the two levels of quarantine had reduced the case number and deaths by almost a half. The results demonstrate how modeling can be useful in qualitative evaluation of the impact of traditional intervention measures for newly emerging infectious diseases outbreak when there is inadequate information on the characteristics and clinical features of the new disease-measures which could become particularly important with the looming threat of global flu pandemic possibly caused by a novel mutating flu strain, including that of avian variety. ? 2006 Elsevier Ltd. All rights reserved. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/160546 http://ntur.lib.ntu.edu.tw/bitstream/246246/160546/1/54.pdf |
DOI: | 10.1016/j.jtbi.2006.09.015 | SDG/Keyword: | avian influenza; disease spread; epidemiology; infectious disease; modeling; mortality risk; numerical model; severe acute respiratory syndrome; article; clinical feature; data analysis; death; epidemic; exposure variable; fowl; human; infection control; influenza; mathematical model; medical record; pandemic; priority journal; qualitative analysis; retrospective study; severe acute respiratory syndrome; simulation; Taiwan; theoretical study; Communicable Diseases, Emerging; Disease Outbreaks; Humans; Mathematics; Models, Biological; Patient Isolation; Quarantine; Retrospective Studies; Severe Acute Respiratory Syndrome; Taiwan; Travel; Asia; Eurasia; Far East; Taiwan; Aves |
Appears in Collections: | 流行病學與預防醫學研究所 |
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