https://scholars.lib.ntu.edu.tw/handle/123456789/113405
標題: | Genome-Wide Scan for Quantitative Ace Activity in Taiwan Young-Onset Hypertension Study | 作者: | WANG, RUEY-YUN CHEN, CHIEN-CHUNG et al. |
關鍵字: | genome-wide scan;hypertension;angiotensin converting enzyme;quantitative trait loci;Chinese;Taiwan | 公開日期: | 2008 | 起(迄)頁: | 85-90 | 來源出版物: | Human Heredity | 摘要: | Objectives: Angiotensin converting enzyme ( ACE) plays major roles in the pathogenesis of cardiovascular diseases ( CVD) . However, findings on the relations between ACE variants and CVD have not been consistent. The purpose of this study was to map quantitative trait loci ( QTL) for serum ACE activity, a heritable endophenotype of cardiovascular diseases ( estimated heritability = 0.58). Methods: With 1, 271 individuals from 373 young- onset ( age <= 40) hypertension pedigrees, 479 deCODE microsatellite markers were genotyped. Results: We identified a previously unknown loci on chromosomes 9 at 149.4 cM ( LOD = 3.00) in addition to a strong linkage peak near the ACE structural locus on chromosome 17 at 89.6 cM ( LOD = 4.60). Conclusions: These results not only indicate that the ACE gene or nearby loci on 17q was among the strongest QTL influencing ACE activity, but also reveal a potential ACE QTL in human genome, pointing to the complexity of ACE regulation. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/173144 | DOI: | 10.1159/000108940 | SDG/關鍵字: | dipeptidyl carboxypeptidase; adult; article; cardiovascular disease; chromosome 17q; chromosome 9; enzyme activity; enzyme regulation; female; gene identification; genome; genotype; human; hypertension; major clinical study; male; pedigree; phenotype; quantitative trait locus; Age of Onset; Cardiovascular Diseases; Female; Genome, Human; Genotype; Humans; Hypertension; Linkage Disequilibrium; Male; Pedigree; Peptidyl-Dipeptidase A; Phenotype; Taiwan |
顯示於: | 流行病學與預防醫學研究所 |
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