https://scholars.lib.ntu.edu.tw/handle/123456789/113410
標題: | Arsenic Exposure, Urinary Arsenic Speciation, and the Incidence of Urothelial Carcinoma: A Twelve-Year Follow-up Study | 作者: | HUANG, YUNG-KAI HUANG, YA-LI HSUEH, YU- MEI YANG, MO-HSIUNG WU, MEEI-MAAN CHEN, SHU-YUAN HSU, LING-I CHEN, CHIEN-JEN |
關鍵字: | urinary arsenic species;long-term arsenic exposure;urothelial carcinoma risk | 公開日期: | 2008 | 起(迄)頁: | 829-839 | 來源出版物: | Cancer Causes & Control | 摘要: | The risk of urothelial carcinoma (UC) and urinary arsenic speciation have been evaluated in a few case-control studies ; however, the association has not been verified in a prospective cohort study. The aim of this study was to examine the association between urinary arsenic speciation and the incidence of UC in a cohort study. A total of 1,078 residents of southwestern Taiwan were followed for an average of 12 years. A high- performance liquid chromatography/hydride generator and an atomic absorption spectrometry were used to measure urinary arsenite, arsenate , monomethylarsonic acid (MMA(V)), and dimethylarsinic acid( DMA(V)). The incidence of UC was estimated by examining the National Cancer Registry of Taiwan between January 1985 and December 2001. There were 37 newly diagnosed cases of UC during a follow-up period of 11,655 person-years. Significantly higher percentages of MMA(V) and lower percentages of DMA(V) existed among the patients with UC than among the healthy residents. After adjustment for age, gender, educational level, and smoking status, the percentage of urinary DMA(V) was shown to have an inverse association with the risk of UC, having a relative risk (RR) of the tertile strata of 1.0, 0.3, and 0.3, respectively (p < 0.05 for the trend test). The RR (95% confidence interval) of residents with a cumulative arsenic exposure (CAE ) of >= 20 mg/l-year and a higher percentage of MMA(V) or a CAE of> = 20 mg/l-year and a lower percentage of DMA(V) was 3.7 (1.2 -11.6) or 4.2 (1.3 -13.4) compared to residents with a CAE of < 20 mg/l-year and a lower percentage of MMA(V) or a CAE of< 20 mg/l-year and a higher percentage of DMA(V) respectively . There was a significant association between inefficient arsenic methylation and the development of UC in the residents in the high CAE exposure strata in an area of southwestern Taiwan endemic for arseniasis. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/173172 | DOI: | 10.1007/s10552-008-9146-5 | SDG/關鍵字: | arsenic; arsenic acid; arsenic trioxide; cacodylic acid; methanearsonic acid; adult; aged; article; atomic absorption spectrometry; cancer risk; carcinoma; cigarette smoking; environmental exposure; female; follow up; high performance liquid chromatography; human; incidence; major clinical study; male; priority journal; species differentiation; Taiwan; urinary arsenic speciation; urothelial carcinoma; Adult; Aged; Arsenic; Arsenic Poisoning; Arsenicals; Cacodylic Acid; Carcinoma, Transitional Cell; Case-Control Studies; Chromatography, High Pressure Liquid; Cohort Studies; Female; Follow-Up Studies; Humans; Incidence; Male; Middle Aged; Prospective Studies; Questionnaires; Spectrophotometry, Atomic; Taiwan; Time Factors; Urinary Bladder Neoplasms |
顯示於: | 流行病學與預防醫學研究所 |
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