https://scholars.lib.ntu.edu.tw/handle/123456789/113416
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor | 流行病學所 | en |
dc.contributor.author | WU, HUI-CHEN | en |
dc.contributor.author | YANG, HWAI-I | en |
dc.contributor.author | TSAI, WEI- YANN | en |
dc.contributor.author | WANG, LI-YU | en |
dc.contributor.author | CHEN, SHU-YUAN | en |
dc.contributor.author | CHEN, CHIEN-JEN | en |
dc.creator | 吳慧真;楊懷壹;蔡偉彥;王豊裕;陳淑媛;陳建仁 | zh-tw |
dc.creator | WU, HUI-CHEN;YANG, HWAI-I;TSAI, WEI- YANN;WANG, LI-YU;CHEN, SHU-YUAN;CHEN, CHIEN-JEN | en |
dc.date | 2008 | en |
dc.date.accessioned | 2009-11-24T03:42:43Z | - |
dc.date.accessioned | 2018-06-29T18:17:42Z | - |
dc.date.available | 2009-11-24T03:42:43Z | - |
dc.date.available | 2018-06-29T18:17:42Z | - |
dc.date.issued | 2008 | - |
dc.identifier.uri | http://ntur.lib.ntu.edu.tw//handle/246246/173201 | - |
dc.description.abstract | To evaluate the role of oxidative stress and aflatoxin exposure on risk of hepatocellular carcinoma (HCC), a case- control study nested within a large community-based cohort was conducted in Taiwan. Baseline urine samples, collected from a total of 74 incident HCC cases and 290 matched controls, were used to determine by enzyme-linked immunosorbent assays the level of urinary 15-F-2t- isoprostane (15-F-2t-IsoP), a biomarker of lipid peroxidation. These samples had been previously analyzed for urinary aflatoxin B1 (AFB(1)) metabolites and 8-oxo-7,8- dihydro-2'- deoxyguanosine (8-oxodG). Pearson partial correlation coefficient analysis showed that urinary AFB1 metabolites and 8-oxodG were significantly associated with the level of urinary 15-F-2t-IsoP. After adjustment for potential confounding factors in a conditional logistic regression model, urinary 15-F-2t-IsoP was significantly associated with risk of HCC [above versus below the mean odds ratio (OR) = 2.53, 95% confidence interval (CI) = 1.30- 4.93]. Moreover, when compared with subjects in the lowest tertile of 15-F-2t-IsoP, there was a trend of increasing risk of HCC ( Ptrend = 0.0008), with adjusted ORs (95% CIs) of 3.87 (1.32-11.38) and 6. 27 (2.17-18.13) for the second and third tertile, respectively. In addition, the combination of urinary 15-F-2t-IsoP above the mean and chronic hepatitis B virus (HBV) infection resulted in an OR of 19.01 (95% CI = 6.67-54.17) compared with those with low urinary 15-F-2t-IsoP and without HBV infection. These results suggest that elevated levels of urinary 15-F-2t-IsoP may be related to increasing level of aflatoxin exposure and are associated with an increased risk of HCC. | en |
dc.language | en-us | en |
dc.language.iso | en_US | - |
dc.relation | CARCINOGENESIS v.29 n.5 pp.971-976 | en |
dc.relation.ispartof | CARCINOGENESIS | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.title | Urinary 15-F-2t-Isoprostane, Aflatoxin B-1 Exposure and Hepatitis B Virus Infection and Hepatocellular Carcinoma in Taiwan | en |
dc.type | journal article | en |
dc.relation.pages | 971-976 | - |
dc.relation.journalvolume | v.29 | - |
dc.relation.journalissue | n.5 | - |
item.languageiso639-1 | en_US | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
顯示於: | 流行病學與預防醫學研究所 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。