https://scholars.lib.ntu.edu.tw/handle/123456789/113419
標題: | The Effect of Betel Quid and Cigarette on Multistate Progression of Oral Pre-Malignancy | 作者: | YEN, AMY MING-FANG CHANG, SHU-HUI 陳秀熙 |
關鍵字: | betel quid;natural history;oral cancer;oral premalignant;lesions;smoking | 公開日期: | 2008 | 卷: | v.37 | 期: | n.7 | 起(迄)頁: | 417-422 | 來源出版物: | JOURNAL OF ORAL PATHOLOGY & MEDICINE | 摘要: | BACKGROUND: Although the effect of betel quid chewing and smoking on oral cancer has been well documented, both influences, dose and duration during life time, on multistate progression of oral pre-malignancy are hardly addressed. METHODS: By recruiting a group of male chewers from different occupation groups, we modeled the effects of both duration and quantity of betel quid chewing and smoking on annual incidence rate of developing leukoplakia and average dwelling times (ADTs) staying in leukoplakia and erythroleukoplakia. RESULTS: The annual incidence rate ( per year) of leukoplakia was estimated as 0.35% (95% CI: 0.22-0. 48%). The ADTs were 24 years for leukoplakia and 7 years for erythroleukoplakia. Annual incidence rate of leukoplakia with high consumption and long duration of betel quid and smoking was higher. Both quantity and duration of smoking and betel quid chewing play minor roles in the influence of ADT . The risks of developing oral cancer after 20 years of follow-up were 42. 2% for leukoplakia and 95.0% for erythroleukoplakia. CONCLUSION: The effects of betel quid chewing and smoking on multistate progressions between oral pre-malignancies were elucidated. These results can be applied to predict long-term risk of malignant transformation varying with different duration and quantity of betel quid and cigarette. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/173221 |
顯示於: | 流行病學與預防醫學研究所 |
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