POLYCYCLIC AROMATIC HYDROCARBON- AND AFLATOXIN-ALBUMIN ADDUCTS, HEPATITIS B VIRUS INFECTION AND HEPATOCELLULAR CARCINOMA IN TAIWAN
Resource
CANCER LETTERS,252(1),104-114.
Journal
Cancer Letters
Pages
104-114
Date Issued
2007
Date
2007
Author(s)
吳慧真
楊懷壹
蔡偉彥
王豊裕
陳淑媛
陳建仁
Abstract
To determine the association between polycyclic aromatic hydrocarbon (PAH) exposure and risk of hepatocellular carcinoma, a case-control study nested within a community-based cohort was conducted in Taiwan. Baseline blood samples, collected from a total of 174 HCC cases and 776 matched controls, were used to determine the level of PAH-albumin adducts by competitive enzyme-linked immunosorbent assay. Conditional logistic regression analysis was used to calculate odds ratios (OR) and 95% confidence intervals (CI) to assess the effect of PAH-albumin adducts on risk of HCC. When compared to subjects in the lowest quantile, there was an increase in risk of HCC, with adjusted ORs (95% CI) of 1.0 (0.5-2.0), 1.2 (0.6-2.4) and 2.0 (1.0-4.2: Ptrend = 0.08) for subjects in the 2nd, 3rd and 4th quantile, respectively. The corresponding adjusted ORs (95% CI) were 1.9 (0.6-6.1), 1.7 (0.6-4.9) and 2.1 (0.5-8.2; Ptrend = 0.22), respectively, among subjects with high AFB1-albumin adducts; and 0.8 (0.3-2.7), 1.5 (0.6-3.5) and 2.9 (1.0-8.6; Ptrend = 0.06), respectively, for those who were chronically infected with hepatitis B virus (HBV). The combination of PAH- and AFB1-albumin adducts above the mean and chronic HBV infection resulted in an OR of 8.2 (95% CI, 3.6-19.0; p < 0.0001), compared to those with low adducts and no viral infection. These results demonstrate that PAH-albumin adducts are associated with an increased risk of HCC, especially among those with high aflatoxin exposure and chronic HBV infection. Environmental PAH exposure seems to enhance the hepatocarcinogenicity of chronic HBV infection. ? 2007 Elsevier Ireland Ltd. All rights reserved.
Subjects
Aflatoxin-albumin adducts; Hepatitis B virus; Hepatocellular carcinoma; PAH-albumin adducts
SDGs
Other Subjects
aflatoxin; albumin; polycyclic aromatic hydrocarbon; adult; article; blood sampling; cancer risk; chronic disease; confidence interval; controlled study; enzyme linked immunosorbent assay; female; hepatitis B; human; liver cell carcinoma; logistic regression analysis; major clinical study; male; priority journal; protein determination; Taiwan; Adult; Aflatoxins; Aged; Albumins; Carcinoma, Hepatocellular; Environmental Exposure; Female; Hepatitis B, Chronic; Humans; Liver Neoplasms; Male; Middle Aged; Polycyclic Hydrocarbons, Aromatic; Risk; Taiwan; Hepatitis B virus
Type
journal article