https://scholars.lib.ntu.edu.tw/handle/123456789/113772
Title: | Hepatitis B virus DNA levels and outcomes in chronic hepatitis B | Other Titles: | Wu MH | Authors: | CHEN, CHIEN-JEN YANG, HWAI-I Iloeje UH REVEAL-HBV Study Group (Liaw YF Jen CL You SL Chen TH Lu SN Yeh SH Sun CA Chen SY Ho SC Lu TG Chen CC Chen DS Chen PJ Hsieh CY Lee HS Yang PM Chen CH Chen JD Huang SP CHYI-FENG JAN How WC Su J, Wu WP Ou TY Shih KC Chung WS Li C Lin CG Wang LY Chu KE) |
Issue Date: | 2009 | Start page/Pages: | S72-S84 | Source: | Hepatology | Abstract: | Serum hepatitis B virus (HBV) DNA levels can fluctuate markedly during the course of chronic HBV infection. Both case-control and cohort studies have shown a significant, dose-response association between serum HBV DNA levels measured at the time of initial evaluation and the subsequent risk of cirrhosis. A similar direct relationship has been shown for the risk of hepatocellular carcinoma (HCC) in cross-sectional, case-control, and cohort studies. Interventional studies have shown a strong correlation between the indices of disease activity seen on liver biopsy and levels of serum HBV DNA. These studies have also shown that reduction in HBV DNA levels correlate strongly with improvements in liver histology. For patients with HCC, prognosis (including risk of death, metastasis, and recurrence following surgery) is worse with higher serum HBV DNA levels. The preponderance of the evidence in the published literature demonstrates that serum HBV DNA level is an important and independent risk factor for disease progression in chronic hepatitis B. The relative importance of serial HBV DNA measurements, the loss of hepatitis B e and surface antigens, as well as the emergence of HBV mutants in the progression of chronic hepatitis B, especially in young patients, is an important need for future research. ? 2009 American Association for the Study of Liver Diseases. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/210483 | DOI: | 10.1002/hep.22884 | SDG/Keyword: | hepatitis B surface antigen; hepatitis B(e) antigen; virus DNA; virus DNA; adult; article; cohort analysis; death; disease activity; disease course; female; hepatitis B; Hepatitis B virus; human; liver biopsy; liver cell carcinoma; liver cirrhosis; liver histology; male; metastasis; nonhuman; priority journal; prognosis; recurrence risk; risk assessment; risk factor; virus mutant; blood; conference paper; consensus development; genetics; growth, development and aging; hepatitis B; virology; DNA, Viral; Hepatitis B virus; Hepatitis B, Chronic; Humans; Risk Factors |
Appears in Collections: | 流行病學與預防醫學研究所 |
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