https://scholars.lib.ntu.edu.tw/handle/123456789/113856
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor | 流行病學與預防醫學研究所 | en |
dc.contributor.author | Loomba, Rohit | en |
dc.contributor.author | Yang, Hwai-I. | en |
dc.contributor.author | Su, Jun | en |
dc.contributor.author | Brenner, David | en |
dc.contributor.author | Iloeje, Uchenna | en |
dc.contributor.author | Chen, Chien-Jen | en |
dc.creator | 楊懷壹;陳建仁 | zh-tw |
dc.creator | Loomba, Rohit; Yang, Hwai-I.; Su, Jun; Brenner, David; Iloeje, Uchenna; Chen, Chien-Jen | en |
dc.date | 2010 | en |
dc.date.accessioned | 2011-06-24T06:57:39Z | - |
dc.date.accessioned | 2018-06-29T18:28:02Z | - |
dc.date.available | 2011-06-24T06:57:39Z | - |
dc.date.available | 2018-06-29T18:28:02Z | - |
dc.date.issued | 2010 | - |
dc.identifier.uri | http://ntur.lib.ntu.edu.tw//handle/246246/235842 | - |
dc.description.abstract | Body mass index (BMI) and alcohol use are risk factors for hepatocellular carcinoma (HCC). We performed a prospective study to determine if these factors have synergistic effects on HCC risk. METHODS: Over 14 years, we followed up 2260 Taiwanese men from the Risk Evaluation of Viral Load Elevation and Associated Liver Disease/Cancer-Hepatitis B Virus (REVEAL- HBV) Study Cohort who tested positive for the hepatitis B surface antigen (mean age, 46 +/- 10 y; mean BMI , 24 +/- 3 kg/m(2)); 20% reported alcohol use. Incident HCC cases were identified via linkage to the national cancer registry. Multivariate-adjusted hazard ratio (HR) and 95% confidence interval (Cl) were estimated using Cox- proportional hazards models. RESULTS: In univariate analysis , the interaction between BMI and alcohol predicted incident HCC (p = .029). Alcohol use and extreme obesity (BMI >= 30 kg/m(2)) had synergistic effects on the risk of incident HCC in analyses adjusted for age (HR, 3.41; 95% CI, 1.25-9.27; P < .025) and multivariables (HR, 3.40; 95% CI, 1.24-9.34; P < .025). The relative risk estimate for the interaction and the attributable proportion from the interaction and synergy index were 1.59, 0.52, and 4.40, respectively; these indicate a multiplicative interaction between alcohol use and extreme obesity. In an analysis stratified into 4 World Health Organization categories of BMI and alcohol use, the risk of incident HCC increased in overweight (HR, 2.4; 95% CI, 1.3-4.4), obese (HR, 2.0; 95% CI , 1.1-3.7), and extremely obese (HR, 2.9; 95% CI, 1.0-8.0) users of alcohol( P for trend = .046). CONCLUSIONS: Obesity and alcohol have synergistic effects to increase the risk of incident HCC in hepatitis B surface antigen-positive men. Lifestyle interventions might reduce the incidence of HCC. | en |
dc.language | en-us | en |
dc.language.iso | en_US | - |
dc.relation | CLINICAL GASTROENTEROLOGY AND HEPATOLOGY v.8 n.10 pp.891-898 | en |
dc.relation.ispartof | Clinical Gastroenterology and Hepatology | en_US |
dc.subject | Hepatocellular Carcinoma | en |
dc.subject | Epidemiology | en |
dc.subject | Cirrhosis | en |
dc.subject | Nutrition | en |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | hepatitis B surface antigen; adult; alcohol consumption; article; body mass; cancer registry; cancer risk; human; liver cell carcinoma; major clinical study; male; obesity | - |
dc.title | Obesity and Alcohol Synergize to Increase the Risk of Incident Hepatocellular Carcinoma in Men | en |
dc.type | journal article | en |
dc.identifier.doi | 10.1016/j.cgh.2010.06.027 | - |
dc.relation.pages | 891-898.e2 | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.languageiso639-1 | en_US | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
顯示於: | 流行病學與預防醫學研究所 |
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