https://scholars.lib.ntu.edu.tw/handle/123456789/113993
標題: | Oseltamivir use and outcomes during the 2009 influenza A H1N1 pandemic in Taiwan | 作者: | Liu, Chia-Hung Wang, Jiun-Ling Su, Chia-Ping Chuang, Jen-Hsiang CHIA-HSUIN CHANG Lai, Mei-Shu |
關鍵字: | Oseltamivir;Influenza A virus;H1N1 subtype;Pandemic;Mortality | 公開日期: | 2013 | 卷: | 13 | 期: | 1 | 起(迄)頁: | 646 | 來源出版物: | BMC Public Health | 摘要: | Background: The Taiwan CDC provided free oseltamivir to all patients with influenza infections confirmed by rapid testing or who had clinical warning symptoms during the 2009 H1N1 influenza pandemic in Taiwan. However, oseltamivir utilization patterns, cost, and outcomes among oseltamivir-treated patients remained unclear. Method: A population-level, observational cohort study was conducted using the Taiwan National Health Insurance Database from January to December 2009 to describe the use of oseltamivir. Result: Prescription trend over weeks increased after a change in government policy and responded to the influenza virus activity. The overall prescription rate was 22.33 per 1000 persons, with the highest prescription rate of 116.5 for those aged 7-12 years, followed by 69.0 for those aged 13-18 years, while the lowest rate was 1.7 for those aged >= 65 years. As influenza virus activity increased, the number of prescriptions for those aged <= 18 years rose significantly, whereas no substantial change was observed for those aged >= 65 years. There were also regional variations in terms of oseltamivir utilization and influenza complication rates. Conclusions: Oseltamivir was widely used in the 2009 H1N1 influenza pandemic in Taiwan, particularly in those aged 7-18 years. The number of prescriptions for oseltamivir increased with a change in government policy and with increasing cases of pandemic influenza. Further study is needed to examine whether there is an over- or under-use of anti-influenza drugs in different age groups or regions and to examine the current policy of public use of anti-influenza drugs to reduce influenza-associated morbidity and mortality. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/259467 http://ntur.lib.ntu.edu.tw/bitstream/246246/259467/1/index.html |
DOI: | 10.1186/1471-2458-13-646 | SDG/關鍵字: | antivirus agent; oseltamivir; adolescent; adult; aged; article; child; cohort analysis; drug effect; economics; factual database; female; human; influenza; Influenza virus A H1N1; isolation and purification; male; middle aged; prescription; public health; statistics; Taiwan; treatment outcome; young adult; Adolescent; Adult; Aged; Antiviral Agents; Child; Cohort Studies; Databases, Factual; Drug Prescriptions; Female; Humans; Influenza A Virus, H1N1 Subtype; Influenza, Human; Male; Middle Aged; National Health Programs; Oseltamivir; Taiwan; Treatment Outcome; Young Adult |
顯示於: | 流行病學與預防醫學研究所 |
檔案 | 描述 | 大小 | 格式 | |
---|---|---|---|---|
index.html | 23.17 kB | HTML | 檢視/開啟 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。