DC 欄位 | 值 | 語言 |
dc.contributor.author | 陳瑞芬 | zh_TW |
dc.creator | 陳瑞芬 | - |
dc.date | 2005 | zh_TW |
dc.date.accessioned | 2006-07-25T09:58:26Z | - |
dc.date.accessioned | 2018-07-06T01:22:14Z | - |
dc.date.available | 2006-07-25T09:58:26Z | - |
dc.date.available | 2018-07-06T01:22:14Z | - |
dc.date.issued | 2005 | - |
dc.identifier | 932311B002034 | zh_TW |
dc.identifier.uri | http://ntur.lib.ntu.edu.tw//handle/246246/10292 | - |
dc.description.abstract | In the present study, the neuronal activities and HR responses to glutamate solution (Glu,
10 mM) stimulation of the cardiac vagal preganglionic neurons (CVPNs) in nucleus
ambiguus (NA) of the 12-16 week old SHR were compared with aged matched normotensive
WKY (Wistar-Kyoto) rats and Wistar rats. Microinjection of different doses of 10 mM Glu
into the NA produced dose-dependent responses of heart rate (HR) in normotensive and
hypertensive rats. The maximal HR changes and threshold dose of Glu were not significantly
different in three strains, but there was a tendency that the threshold dose of SHR was largest,
then that of WKY rats and Wistar rats. The saturation dose of Glu to elicit the maximal HR
change was also significantly larger in SHR than that in Wistar rats. The maximal slope of
dose-response curve in Wistar rats is steepest in three strains. The results suggested that the
reactivity of CVPNs in NA to Glu stimulation might be lower in SHR than that in Wistar rats.
Most neurons in NA had respiratory firing patterns, few pulse-related neurons were observed
in three strains of rats. | en |
dc.description.abstract | 本計畫利用自發性高血壓大鼠(Spontaneously hypertensive rat;SHR)(9-12 週齡)為
高血壓模式動物,並以其同齡近親正常血壓之WKY(Wistar-Kyoto rat)及一般的Wistar 鼠
為對照組,來探討高血壓動物控制心臟的副交感神經系統是否產生異常。本實驗採用可
以同時紀錄神經元活性和注射藥物的玻璃電極,在延腦閂門附近的疑核(Nucleus
Ambiguus; NA)區域,以麩氨酸(L-glutamate 10 mM, Glu)刺激,進行降心跳反應的劑量
-反應實驗,以最大反應、閾值反應和劑量-反應曲線的斜率,來比較三種大鼠延腦副
交感神經機構之反應性;同時亦記錄明顯降心跳反應位置的神經元活性,分析其神經元
的放電型態。實驗結果發現,雖然三種大鼠的最大降心跳反應與閾值劑量沒有統計上的
差異,但是有趨勢顯示SHR所需的閾值劑量與飽和劑量均較大。而且造成最大降心跳反
應的飽和劑量在SHR中明顯大於正常血壓鼠;劑量-反應曲線的斜率則以Wistar鼠為最
大。由實驗結果推測,SHR的疑核可能對麩胺酸刺激的反應性變低,需要較大的刺激才
會引起最大的降心跳反應。在三種大鼠的疑核中,大多數神經元具有呼吸節律的放電活
性,具有心跳節律的神經元活性極少。 | zh_TW |
dc.format | application/pdf | zh_TW |
dc.format.extent | 419912 bytes | - |
dc.format.mimetype | application/pdf | - |
dc.language | zh-TW | zh_TW |
dc.language.iso | zh_TW | - |
dc.publisher | 臺北市:國立臺灣大學生命科學系 | zh_TW |
dc.rights | 國立臺灣大學生命科學系 | zh_TW |
dc.subject | 疑核 | zh_TW |
dc.subject | 自發性高血壓大鼠 | zh_TW |
dc.subject | 心搏徐緩 | zh_TW |
dc.subject | 麩氨酸 | zh_TW |
dc.subject | 心臟副交感神經元活性 | zh_TW |
dc.subject | nucleus ambiguous | en |
dc.subject | SHR | en |
dc.subject | bradycardia | en |
dc.subject | glutamate | en |
dc.subject | cardiac vagal preganglionic neuron | en |
dc.title | 正常血壓及高血壓大鼠延腦心臟副交感神經元活性及中樞連結之比較 | zh_TW |
dc.type | report | en |
dc.identifier.uri.fulltext | http://ntur.lib.ntu.edu.tw/bitstream/246246/10292/1/932311B002034.pdf | - |
dc.coverage | 計畫年度:93;起迄日期:2004-08-01/2005-07-31 | zh_TW |
item.languageiso639-1 | zh_TW | - |
item.cerifentitytype | Publications | - |
item.fulltext | with fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_93fc | - |
item.openairetype | report | - |
item.grantfulltext | open | - |
crisitem.author.orcid | 0000-0002-7505-5415 | - |
顯示於: | 生命科學系
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