Repository logo
  • English
  • 中文
Log In
Have you forgotten your password?
  1. Home
  2. College of Life Science / 生命科學院
  3. Life Science / 生命科學系
  4. The role of Endothelin-1 in acute regulation of acid secretion upon acid challenge in zebrafish
 
  • Details

The role of Endothelin-1 in acute regulation of acid secretion upon acid challenge in zebrafish

Date Issued
2014
Date
2014
Author(s)
Wang, Jung-Hsuan
URI
http://ntur.lib.ntu.edu.tw//handle/246246/261674
Abstract
Water area acidification caused by industrial pollution and climate change has threatened the survival of aquatic habitants. As a primary link between environmental changes and physiological responses, the role of neuroendocrine system in acid-base regulation under pH disturbance in fish remains unclear. Previous study indicated that Endothelin-1 (EDN1) was involved in regulation of skin acid secretion in zebrafish embryos. The aim of this study is to explore the role of EDN1 in acute regulation of acid secretion upon acidic challenge in fish. The results showed that skin acid secretion of zebrafish embryos was stimulated in 6hr after low pH (pH4) treatment, but no concomitant changes were observed on the expression of H+-ATPase (HA). Expression of EDN1was also increased in 4hr after treatment while the expression of other hormones increase at latter timepoints. Moreover, the expression of ionocyte differentiation factors increased in 12hr after treatment, implying the long-term regulatory mechanism to acidic stress may be turned on in a latter stage and the involvement of EDN1 in short-term regulation of acid secretion. During acclimation to moderate acid conditions (pH 5.5), expression of EDN1 was upregulated while no significant difference was observed in the transcription levels of H+-ATPase and ionocyte differentiation factor, implying that EDN1 may be involved in regulating moderate acid challenge.
Subjects
內皮激素
斑馬魚
離子細胞
酸適應
SDGs

[SDGs]SDG11

[SDGs]SDG13

Type
thesis
File(s)
Loading...
Thumbnail Image
Name

ntu-103-R01b41019-1.pdf

Size

23.32 KB

Format

Adobe PDF

Checksum

(MD5):49b6211acc583c9666370c3d76a34dc0

臺大位居世界頂尖大學之列,為永久珍藏及向國際展現本校豐碩的研究成果及學術能量,圖書館整合機構典藏(NTUR)與學術庫(AH)不同功能平台,成為臺大學術典藏NTU scholars。期能整合研究能量、促進交流合作、保存學術產出、推廣研究成果。

To permanently archive and promote researcher profiles and scholarly works, Library integrates the services of “NTU Repository” with “Academic Hub” to form NTU Scholars.

總館學科館員 (Main Library)
醫學圖書館學科館員 (Medical Library)
社會科學院辜振甫紀念圖書館學科館員 (Social Sciences Library)

開放取用是從使用者角度提升資訊取用性的社會運動,應用在學術研究上是透過將研究著作公開供使用者自由取閱,以促進學術傳播及因應期刊訂購費用逐年攀升。同時可加速研究發展、提升研究影響力,NTU Scholars即為本校的開放取用典藏(OA Archive)平台。(點選深入了解OA)

  • 請確認所上傳的全文是原創的內容,若該文件包含部分內容的版權非匯入者所有,或由第三方贊助與合作完成,請確認該版權所有者及第三方同意提供此授權。
    Please represent that the submission is your original work, and that you have the right to grant the rights to upload.
  • 若欲上傳已出版的全文電子檔,可使用Open policy finder網站查詢,以確認出版單位之版權政策。
    Please use Open policy finder to find a summary of permissions that are normally given as part of each publisher's copyright transfer agreement.
  • 網站簡介 (Quickstart Guide)
  • 使用手冊 (Instruction Manual)
  • 線上預約服務 (Booking Service)
  • 方案一:臺灣大學計算機中心帳號登入
    (With C&INC Email Account)
  • 方案二:ORCID帳號登入 (With ORCID)
  • 方案一:定期更新ORCID者,以ID匯入 (Search for identifier (ORCID))
  • 方案二:自行建檔 (Default mode Submission)
  • 方案三:學科館員協助匯入 (Email worklist to subject librarians)

Built with DSpace-CRIS software - Extension maintained and optimized by 4Science