Negative regulation of Caenorhabditis elegans epidermal damage responses by death-associated protein kinase
Resource
Proceedings of the National Academy of Sciences 106 (5): 1457-1461
Journal
Proceedings of the National Academy of Sciences
Journal Volume
106
Journal Issue
5
Pages
1457-1461
Date Issued
2009
Date
2009
Author(s)
Tong, Amy
Lynn, Grace
Ngo, Vy
Wong, Daniel
Moseley, Sarah L.
Ewbank, Jonathan J.
Goncharov, Alexandr
Pujol, Nathalie
Chisholm, Andrew D.
Abstract
Wounding of epidermal layers triggers multiple coordinated responses to damage. We show here that the Caenorhabditis elegans ortholog of the tumor suppressor death-associated protein kinase, dapk-1, acts as a previously undescribed negative regulator of barrier repair and innate immune responses to wounding. Loss of DAPK-1 function results in constitutive formation of scar-like structures in the cuticle, and up-regulation of innate immune responses to damage. Overexpression of DAPK-1 represses innate immune responses to needle wounding. Up-regulation of innate immune responses in dapk-1 requires the TIR-1/p38 signal transduction pathway; loss of function in this pathway synergizes with dapk-1 to drastically reduce adult lifespan. Our results reveal a previously undescribed function for the DAPK tumor suppressor family in regulation of epithelial damage responses.
Type
journal article
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