https://scholars.lib.ntu.edu.tw/handle/123456789/136487
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor | 外科部;病理學科;生命科學系;毒理所;小兒部;外科;婦產科 | zh_tw |
dc.contributor.author | Hsu, Wen-Ming | en_US |
dc.contributor.author | Jen, Yung-Ming | en_US |
dc.contributor.author | Lee, Hsinyu | en_US |
dc.contributor.author | Kuo, Min-Liang | en_US |
dc.contributor.author | Tsao, Po-Nien | en_US |
dc.contributor.author | Chen, Chiung-Nien | en_US |
dc.contributor.author | DAR-MING LAI | en_US |
dc.contributor.author | Lin, Ming-Tsan | en_US |
dc.contributor.author | Lai, Hong-Shiee | en_US |
dc.contributor.author | Chen, Wei-Jao | en_US |
dc.contributor.author | FON-JOU HSIEH | en_US |
dc.creator | Hsu, Wen-Ming; Jen, Yung-Ming; Lee, Hsinyu; Kuo, Min-Liang; Tsao, Po-Nien; Chen, Chiung-Nien; Lai, Dar-Ming; Lin, Ming-Tsan; Lai, Hong-Shiee; Chen, Wei-Jao; Hsieh, Fon-Jou | en |
dc.creator | 許文明;鄭永銘;李心予;郭明良;曹伯年;陳炯年;賴達明;林明燦;賴鴻緒;陳維昭;謝豐舟 | zh_tw |
dc.date | 2006 | en |
dc.date.accessioned | 2009-06-24T05:56:16Z | - |
dc.date.accessioned | 2018-07-06T01:29:49Z | - |
dc.date.available | 2009-06-24T05:56:16Z | - |
dc.date.available | 2018-07-06T01:29:49Z | - |
dc.date.issued | 2006 | - |
dc.identifier.issn | 1068-9265 | - |
dc.identifier.uri | http://ntur.lib.ntu.edu.tw//handle/246246/161550 | - |
dc.identifier.uri | http://ntur.lib.ntu.edu.tw/bitstream/246246/161550/1/13.pdf | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-31544443597&doi=10.1245%2fASO.2006.10.012&partnerID=40&md5=101c0714b4e343e85e14732d66d84df5 | - |
dc.description.abstract | BACKGROUND: Molecular markers greatly affect the outcome of neuroblastoma. This study evaluated the influence of Trk-A and myelocytomatosis viral-related oncogene, neuroblastoma- derived (MYCN) on the role of surgery in advanced neuroblastoma. METHODS: Ten stage 3 and 35 stage 4 neuroblastoma patients were included. Tumor resection was classified into gross total resection (GTR) and incomplete resection. Patients were classified into three biological risk groups according to Trk-A expression and myelocytomatosis viral-related oncogene, neuroblastoma- derived (MYCN) status in tumor tissues studied by immunohistochemistry and fluorescence in situ hybridization, respectively: low risk (positive Trk-A and normal MYCN), intermediate risk (negative Trk-A and normal MYCN), and high risk (positive or negative Trk-A and MYCN amplification). The effect of tumor resection on prognosis was studied and stratified according to the risk grouping. RESULTS: GTR was achieved in 21 patients (46.7%) with a higher complication rate (33% vs. 8% in the incomplete resection group, P = .036 ). GTR was easier to achieve in low-risk tumors than in intermediate- or high-risk tumors (12 of 13, 4 of 17, and 5 of 15, respectively; P < .001). GTR predicted a favorable prognosis for intermediate-risk patients (P = .037; log-rank test), but not for low- or high-risk patients because of the overall favorable and poor prognosis, respectively. CONCLUSIONS: GTR carries a potentially higher possibility of complication. Although GTR can be achieved easily in low- risk neuroblastoma patients with a favorable prognosis, surgeons should do their best to achieve GTR for intermediate-risk patients to improve outcome. Nevertheless, sacrificing vital organs to achieve GTR for high-risk patients is not justified. | en_US |
dc.format | application/pdf | en |
dc.format.extent | 367902 bytes | - |
dc.format.mimetype | application/pdf | - |
dc.language | en | en |
dc.language.iso | en_US | en_US |
dc.relation.ispartof | Annals of Surgical Oncology | en_US |
dc.subject | Child Child | en_US |
dc.subject | Preschool Decision Making Female Humans Infant | en_US |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | biological factor; cisplatin; cyclophosphamide; epirubicin; etoposide; protein tyrosine kinase A; article; cancer staging; cancer surgery; cancer tissue; clinical article; clinical protocol; controlled study; female; fluorescence in situ hybridization; high risk population; human; human tissue; immunohistochemistry; log rank test; male; myeloid leukemia; neuroblastoma; prognosis; treatment indication; virus oncogene; Child; Child, Preschool; Decision Making; Female; Humans; Infant; Male; Multivariate Analysis; Neuroblastoma; Nuclear Proteins; Oncogene Proteins; Prognosis; Proportional Hazards Models; Receptor, trkA; Risk Assessment; Survival Rate; Taiwan; Tumor Markers, Biological | - |
dc.title | The Influence of Biologic Factors on the Surgical Decision in Advanced Neuroblastoma | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1245/ASO.2006.10.012 | - |
dc.identifier.pmid | 16418884 | - |
dc.identifier.scopus | 2-s2.0-31544443597 | - |
item.fulltext | with fulltext | - |
item.grantfulltext | open | - |
dc.relation.pages | 238-244 | en_US |
dc.relation.journalvolume | v.13 | en_US |
dc.relation.journalissue | n.2 | en_US |
dc.identifier.uri.fulltext | http://ntur.lib.ntu.edu.tw/bitstream/246246/161550/1/13.pdf | - |
item.languageiso639-1 | en_US | - |
item.fulltext | with fulltext | - |
item.grantfulltext | open | - |
item.openairetype | journal article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | Surgery-NTUH | - |
crisitem.author.dept | Surgery | - |
crisitem.author.dept | Biomedical Electronics and Bioinformatics | - |
crisitem.author.dept | Life Science | - |
crisitem.author.dept | Center for Biotechnology | - |
crisitem.author.dept | Electrical Engineering | - |
crisitem.author.dept | Pediatrics | - |
crisitem.author.dept | Pediatrics-NTUH | - |
crisitem.author.dept | Surgery | - |
crisitem.author.dept | Surgery-NTUH | - |
crisitem.author.dept | Surgery-NTUH | - |
crisitem.author.dept | Surgery | - |
crisitem.author.dept | Surgery | - |
crisitem.author.dept | Surgery-NTUH | - |
crisitem.author.dept | Surgery | - |
crisitem.author.dept | Surgery-NTUH | - |
crisitem.author.orcid | 0000-0002-5145-9538 | - |
crisitem.author.orcid | 0000-0002-1477-0183 | - |
crisitem.author.orcid | 0000-0002-6114-1769 | - |
crisitem.author.orcid | 0000-0003-1192-5220 | - |
crisitem.author.orcid | 0000-0002-9896-5251 | - |
crisitem.author.orcid | 0000-0001-7313-7057 | - |
crisitem.author.orcid | 0000-0002-7958-2183 | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Electrical Engineering and Computer Science | - |
crisitem.author.parentorg | College of Life Science | - |
crisitem.author.parentorg | Others: University-Level Research Centers | - |
crisitem.author.parentorg | College of Electrical Engineering and Computer Science | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 生命科學系 |
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