https://scholars.lib.ntu.edu.tw/handle/123456789/136502
標題: | Lysophosphatidic Acid Inhibits Serum Deprivation-Induced Autophagy in Human Prostate Cancer PC-3 Cells | 作者: | Chang, Chi-Lun Liao, Jia-Jun Huang, Wei-Pang Lee, Hsinyu |
公開日期: | 2007 | 卷: | 3 | 期: | 3 | 起(迄)頁: | 268-270 | 來源出版物: | Autophagy | 摘要: | Lysophosphatidic acid (LPA) is a platelet-enriched bioactive lysophospholipid. By binding to its cognitive G protein-coupled receptors, which are encoded by endothelial differentiation genes (edgs), LPA regulates various cellular activities including proliferation, survival, and migration. Currently, little is known about the influences of LPA on autophagy, a pivotal mechanism for cell survival during conditions of starvation. Herein we present data indicating that LPA attenuates starvation-induced autophagy, by monitoring the percentage of LC3-II, an autophagy indicator, in human prostate PC-3 cells. In addition, by using cells stably expressing EGFP-LC3, LPA is shown to inhibit the formation of autophagosomes in serum-starved conditions. Our results suggest that in these conditions, LPA inhibits autophagy, which might facilitate early cancer development. ?2007 Landes Bioscience. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/161565 http://ntur.lib.ntu.edu.tw/bitstream/246246/161565/1/20.pdf http://www.scopus.com/inward/record.url?eid=2-s2.0-34248570640&partnerID=MN8TOARS |
DOI: | 10.4161/auto.3909 | SDG/關鍵字: | lysophosphatidic acid; article; autophagy; cancer cell; carcinogenesis; cell activity; cell differentiation; cell migration; cell survival; endothelium cell; human; human cell; male; prostate carcinoma; protein expression |
顯示於: | 生命科學系 |
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