https://scholars.lib.ntu.edu.tw/handle/123456789/136669
標題: | Compounds from Wedelia chinensis synergistically suppress androgen activity and growth in prostate cancer cells | 作者: | Lin, Feng-Min Chen, Li-Ru Lin, En-Hau Ke, Ferng-Chun Chen, Hsin-Yi Tsai, Meng-Jen Hsiao, Pei-Wen |
公開日期: | 2007 | 起(迄)頁: | 2521-2529 | 來源出版物: | Carcinogenesis | 摘要: | Chronic inflammation can augment tumor development in various types of cancers, including prostate cancer (PCa). Reduction of inflammation is therefore an important anticancer therapeutic opportunity. Here, we report four anti-proliferative phytocompounds in Wedelia chinensis, an oriental herbal medicine, identified through their ability to modulate the androgen receptor (AR) activation of transcription from prostate-specific antigen promoter in PCa cells. The 50% inhibition concentration values of indole-3-carboxylaldehyde, wedelolactone, luteolin and apigenin, were 34.9, 0.2, 2.4 and 9.8 μM, respectively. A formula that combined the phytocompounds in the same proportions as in the herbal extract decreased the dosage of each compound required to achieve maximal AR inhibition. In correlation with the AR suppression effect, these active compounds specifically inhibited the growth of AR-dependent PCa cells and as a combination formula they also synergistically suppressed growth in AR-dependent PCa cells. Our study has identified synergistic effects of active compounds in W. chinensis and demonstrated their potential in PCa prevention and therapy. The paradigm of multiple activities and synergism is a useful framework to investigate the therapeutic effects of whole extracts from assorted medicinal plant species. ? The Author 2007. Published by Oxford University Press. All rights reserved. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/161737 | DOI: | 10.1093/carcin/bgm137 | SDG/關鍵字: | androgen; androgen receptor; apigenin; indole 3 carboxyaldehyde; indole derivative; luteolin; plant extract; prostate specific antigen; unclassified drug; Wedelia chinensis extract; wedelolactone; article; cancer cell culture; carcinogenesis; cell growth; cell proliferation; concentration (parameters); controlled study; correlation analysis; drug structure; growth inhibition; herbal medicine; high performance liquid chromatography; hormone inhibition; human; human cell; male; medicinal plant; oriental medicine; priority journal; promoter region; prostate cancer; transcription initiation; Wedelia; Wedelia chinensis; Androgen Antagonists; Anticarcinogenic Agents; Antineoplastic Agents, Phytogenic; Apigenin; Cell Line, Tumor; Cell Proliferation; Coumarins; Drug Synergism; Humans; Indoles; Luteolin; Male; Neoplasms, Hormone-Dependent; Plant Extracts; Prostate-Specific Antigen; Prostatic Neoplasms; Receptors, Androgen; Wedelia |
顯示於: | 生命科學系 |
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