Compounds from Wedelia chinensis synergistically suppress androgen activity and growth in prostate cancer cells
Resource
Carcinogenesis 28 (12): 2521-2529
Journal
Carcinogenesis
Pages
2521-2529
Date Issued
2007
Date
2007
Author(s)
Lin, Feng-Min
Chen, Li-Ru
Lin, En-Hau
Ke, Ferng-Chun
Chen, Hsin-Yi
Tsai, Meng-Jen
Hsiao, Pei-Wen
Abstract
Chronic inflammation can augment tumor development in various types of cancers, including prostate cancer (PCa). Reduction of inflammation is therefore an important anticancer therapeutic opportunity. Here, we report four anti-proliferative phytocompounds in Wedelia chinensis, an oriental herbal medicine, identified through their ability to modulate the androgen receptor (AR) activation of transcription from prostate-specific antigen promoter in PCa cells. The 50% inhibition concentration values of indole-3-carboxylaldehyde, wedelolactone, luteolin and apigenin, were 34.9, 0.2, 2.4 and 9.8 μM, respectively. A formula that combined the phytocompounds in the same proportions as in the herbal extract decreased the dosage of each compound required to achieve maximal AR inhibition. In correlation with the AR suppression effect, these active compounds specifically inhibited the growth of AR-dependent PCa cells and as a combination formula they also synergistically suppressed growth in AR-dependent PCa cells. Our study has identified synergistic effects of active compounds in W. chinensis and demonstrated their potential in PCa prevention and therapy. The paradigm of multiple activities and synergism is a useful framework to investigate the therapeutic effects of whole extracts from assorted medicinal plant species. ? The Author 2007. Published by Oxford University Press. All rights reserved.
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Other Subjects
androgen; androgen receptor; apigenin; indole 3 carboxyaldehyde; indole derivative; luteolin; plant extract; prostate specific antigen; unclassified drug; Wedelia chinensis extract; wedelolactone; article; cancer cell culture; carcinogenesis; cell growth; cell proliferation; concentration (parameters); controlled study; correlation analysis; drug structure; growth inhibition; herbal medicine; high performance liquid chromatography; hormone inhibition; human; human cell; male; medicinal plant; oriental medicine; priority journal; promoter region; prostate cancer; transcription initiation; Wedelia; Wedelia chinensis; Androgen Antagonists; Anticarcinogenic Agents; Antineoplastic Agents, Phytogenic; Apigenin; Cell Line, Tumor; Cell Proliferation; Coumarins; Drug Synergism; Humans; Indoles; Luteolin; Male; Neoplasms, Hormone-Dependent; Plant Extracts; Prostate-Specific Antigen; Prostatic Neoplasms; Receptors, Androgen; Wedelia
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