https://scholars.lib.ntu.edu.tw/handle/123456789/136944
標題: | In Situ Detection of Chromogranin A Released from Living Neurons with a Single-Walled Carbon-Nanotube Field-Effect Transistor | 作者: | Wang, Chen-Wei Pan, Chien-Yuan Wu, Hsing-Chen Shih, Po-Yuan Tsai, Chia-Chang Liao, Kuo-Tang Lu, Li-Long Hsieh, Wen-Hsing Chen, Chii-Dong Chen, Yit-Tsong |
關鍵字: | Biosensors; Carbon nanotubes; Field-effect transistors; Neurons | 公開日期: | 2007 | 起(迄)頁: | 1350-1355 | 來源出版物: | Small | 摘要: | The in situ detection of chromogranin A (CgA) released from living neurons with a single-walled carbon-nanotubes (SWCNT) field-effect transistors (FET) was analyzed. It was found that the chromogranin (CgA) released from the synaptic terminal of neurons can be detected in situ by CgA-Ab/SWCNT-FETs with high selectivity, sensitivity, and real time detection capability. This sensory technique showed promise in medical diagnosis and can further be applied to study the activity of individual neurons, which should open a new window to enlighten the neurophysiology in neuronal networks. Several one-dimensional semiconducting materials such as silicon nanowires, carbon nanotubes, and indium oxide nanowires have been applied as sensing elements to construct NT/NW-FETs for a variety of successful detections of proteins, nucleic acids, cancer markers, and viruses. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/162065 http://ntur.lib.ntu.edu.tw/bitstream/246246/162065/3/s07.pdf |
DOI: | 10.1002/smll.200600723 | SDG/關鍵字: | Biosensors; Diagnosis; Field effect transistors; Neurons; Semiconductor materials; Single-walled carbon nanotubes (SWCN); Chromogranin (CgA); Sensory techniques; Silicon nanowires; Proteins; carbon nanotube; chromogranin A; animal; article; brain cortex; cell culture; chemistry; equipment; equipment design; evaluation; genetic procedures; instrumentation; metabolism; methodology; microelectrode; nanotechnology; nerve cell; particle size; physiology; rat; semiconductor; Sprague Dawley rat; synaptic transmission; ultrastructure; Animals; Biosensing Techniques; Cells, Cultured; Cerebral Cortex; Chromogranin A; Equipment Design; Equipment Failure Analysis; Microelectrodes; Nanotechnology; Nanotubes, Carbon; Neurons; Particle Size; Rats; Rats, Sprague-Dawley; Synaptic Transmission; Transistors |
顯示於: | 生命科學系 |
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