Striatal volume changes in a rat model of childhood attention-deficit/hyperactivity disorder
Resource
PSYCHIATRY RESEARCH, 179(3), 338-341
Journal
Psychiatry Research
Journal Volume
179
Journal Issue
3
Pages
338-341
Date Issued
2010
Date
2010
Author(s)
Abstract
Attention-deficit/hyperactivity disorder (ADHD) is one of the most common childhood neuropsychiatric disorders. Based on neuroimaging studies, the striatum is reported to be abnormal in size, but it is still not clear how they change during developmental stages. Spontaneously hypertensive rats (SHRs) are the commonly used animal model for ADHD. We investigated volume differences of the striatum at various ages before puberty in SHRs versus a control strain, Wistar-Kyoto rats (WKYs). Volumes of the bilateral striatum were measured using micrographs of Nissl-stained serial sections in both strains of rats at the ages of 4, 5, 6, 7, 8, 9, and 10. weeks (n= 4, each strain at each age). The results demonstrated that the age of a significant striatal volume difference between SHRs and WKYs was 5. weeks; however, there was no significant difference for the corresponding total brain volume at each matched age. It suggested that the timing for striatal abnormalities in ADHD occurs during an early stage of childhood. © 2009 Elsevier Ireland Ltd.
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journal article
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