https://scholars.lib.ntu.edu.tw/handle/123456789/138123
標題: | Stimulated resistin expression in white adipose of rats with bile duct ligation-induced liver cirrhosis: relationship to cirrhotic hyperinsulinemia and increased tumor necrosis factor-alpha | 作者: | Lin, Shih-Yi Wayne, Huey-Herng Sheu Chen, Wen-Yin Lee, Fa-Yauh Huang, Ching-Jang |
關鍵字: | Hyperinsulinemia;Liver cirrhosis;Resistin;Tumor necrosis factor- | 公開日期: | 18-一月-2005 | 出版社: | Taipei:National Taiwan University Dept Chem Engn | 起(迄)頁: | - | 來源出版物: | Molecular & Cellular Endocrinology 232, 1–8 | 摘要: | Resistin, an adipose-derived polypeptide hormone, is proposed as a candidate of insulin resistance, although its roles in inhibiting adipogenesis & in inflammation have also been suggested. Liver cirrhosis is characterized by elevated circulating proinflammatory cytokines, including tumor necrosis factor- (TNF-), hyperinsulinemia & insulin resistance. The study aimed to examine resistin expression & its association with insulin & TNF- in a cirrhotic rat model using bile duct ligation (BDL). The BDL-induced cirrhotic rats showed significantly lower fat mass, insulin sensitivity & elevated plasma insulin & TNF- compared to sham animals. In addition, epididymal TNF- & resistin mRNA & protein levels were higher in cirrhotic rats. In normal control rats, in vivo insulin infusion & ex vivo administration of TNF- to cultured fat pads increased resistin gene expression significantly. These results implied that hyperinsulinemia & increased TNF- levels might upregulate adipose resistin gene in BDL-induced liver cirrhosis. Further study is necessary to document the role of resistin in metabolic abnormalities of liver cirrhosis. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/2006111501222468 | 其他識別: | 246246/2006111501222468 |
顯示於: | 生化科技學系 |
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