https://scholars.lib.ntu.edu.tw/handle/123456789/138129
標題: | Inhibition of the Epstein–Barr Virus Lytic Cycle by Andrographolide | 作者: | Lin, Tsuey-Pin Chen, Shih-Ying Duh, Pin-Der Chang, Li-Kwan Liu, Yen-Ni |
關鍵字: | Andrographis paniculata; Andrographolide; Antiviral activity; Epstein-Barr virus | 公開日期: | 2008 | 出版社: | The Pharmaceutical Society of Japan Production services International Academic Publishing Co., Ltd. | 卷: | 31 | 期: | 11 | 起(迄)頁: | 2018-2023 | 來源出版物: | Biological & Pharmaceutical Bulletin | 摘要: | Andrographis paniculata NEES is a medicinal plant that is commonly used in Asia. This work demonstrates that 25 μg/ml of ethanolic extract from A. paniculata (EEAP) and 5m g/ml of andrographolide, a bioactive compound in EEAP, effectively inhibit the expression of Epstein-Barr virus (EBV) lytic proteins, Rta, Zta and EA-D, during the viral lytic cycle in P3HR1 cells. Transient transfection analysis revealed that the lack of expression of Rta, Zta and EA-D is caused by the inhibition of the transcription of BRLF1 and BZLF1, two EBV immediate-early genes that encode Rta and Zta, respectively. This study finds that the inhibition prevents the virus from producing mature viral particles. Meanwhile, andrographolide is not toxic to P3HR1 cells when the concentration is below 5 μg/ml, indicating that the compound is potentially useful as an anti-EBV drug. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/162435 https://www.scopus.com/inward/record.uri?eid=2-s2.0-55549135380&doi=10.1248%2fbpb.31.2018&partnerID=40&md5=45e569bd25b3b72cd8ac09c6b1b14b4b |
ISSN: | 13475215 | DOI: | 10.1248/bpb.31.2018 |
顯示於: | 生化科技學系 |
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