Properties of Astaxanthin/Ca2+ Complex Formation in the Deceleration of Cis/Trans Isomerization
Resource
Organic Letters 9 (16): 2985-2988
Journal
Organic Letters
Journal Volume
9
Journal Issue
16
Pages
2985-2988
Date Issued
2007
Date
2007
Author(s)
Abstract
Deceleration of the regioselective cis/trans isomerization of all-trans-astaxanthin (ASTX) in the presence of Ca2+ was shown by HPLC analysis. The NMR and ITC analyses provided evidence for complexation of ASTX with Ca2+ in 1:2 stoichiometry via chelation at both carbonyl and hydroxyl groups. The rotation across torsion omega6 (C5-C6-C7-C8) upon complexation is consistent with the NOE between 7-H and 5-CH3. This study supports the inhibitory effect of ASTX on calcium-induced turbidity of lens crystallins.
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