https://scholars.lib.ntu.edu.tw/handle/123456789/143897
DC 欄位 | 值 | 語言 |
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dc.contributor.author | Chu, Po-Chen | en |
dc.contributor.author | Yang, Yuh-Cheng | en |
dc.contributor.author | Lu, Yen-Ta | en |
dc.contributor.author | Chen, Hsiang-Ting | en |
dc.contributor.author | Yu, Lung-Chih | en |
dc.contributor.author | Chang, Mau-Sun | en |
dc.creator | Chu, Po-Chen; Yang, Yuh-Cheng; Lu, Yen-Ta; Chen, Hsiang-Ting; Yu, Lung-Chih; Chang, Mau-Sun | - |
dc.date | 2006 | en |
dc.date.accessioned | 2009-08-05T05:53:49Z | - |
dc.date.accessioned | 2018-07-06T06:23:53Z | - |
dc.date.available | 2009-08-05T05:53:49Z | - |
dc.date.available | 2018-07-06T06:23:53Z | - |
dc.date.issued | 2006 | - |
dc.identifier.uri | http://ntur.lib.ntu.edu.tw//handle/246246/163232 | - |
dc.identifier.uri | http://ntur.lib.ntu.edu.tw/bitstream/246246/163232/1/12.pdf | - |
dc.description.abstract | Human p29 is a newly identified nuclear protein whose function is largely undetermined. We found that p29 associated with chromatin, interacted with MCM3, and localized with proliferating cell nuclear antigen foci in the S phase. Silencing of p29 using small interfering RNA duplexes reduced DNA synthesis and increased the expression of p107, a member of the RB family, and of cyclin-dependent kinase inhibitor p21, accompanied with a decreased expression of DNA polymerase α. Lethal events consisting of premature chromatin condensation with a reduced Chk1 phosphorylation were observed in p29-depleted cells in response to UV irradiation. Intriguingly, the phosphorylation of ataxia telangectasia-mutated kinases at S1981 was suppressed in p29-depleted HeLa cells with UV irradiation, but not in hydroxyurea- and ionizing radiation-treated cells. Taken together, these results reveal a novel function of p29 in the regulation of DNA replication checkpoint responses. ?2006 American Association for Cancer Research. | - |
dc.format | application/pdf | en |
dc.format.extent | 563925 bytes | - |
dc.format.mimetype | application/pdf | - |
dc.language | en | en |
dc.language.iso | en_US | - |
dc.relation | Cancer Research 66 (17): 8484-8491 | en |
dc.relation.ispartof | Cancer Research | en_US |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | ATM protein; carrier protein; checkpoint kinase 1; cyclin dependent kinase inhibitor; cyclin dependent kinase inhibitor 1A; cycline; DNA directed DNA polymerase alpha; hydroxyurea; minichromosome maintenance protein 3; nuclear protein; protein p107; protein p29; retinoblastoma protein; small interfering RNA; unclassified drug; apoptosis; article; cell cycle S phase; chromatin; chromatin condensation; controlled study; depletion; DNA damage; DNA replication; DNA synthesis; gene silencing; genotoxicity; HeLa cell; human; human cell; ionizing radiation; nucleotide sequence; priority journal; protein expression; protein function; protein localization; protein phosphorylation; protein protein interaction; ultraviolet irradiation; Apoptosis; DNA; DNA Damage; DNA Replication; Gene Silencing; Hela Cells; Humans; Mitosis; Nuclear Proteins; RNA, Small Interfering; Ultraviolet Rays | - |
dc.title | Silencing of p29 Affects DNA Damage Responses with UV Irradiation | en |
dc.type | journal article | en |
dc.identifier.doi | 10.1158/0008-5472.CAN-05-3229 | - |
dc.identifier.scopus | 2-s2.0-33749002877 | - |
item.fulltext | with fulltext | - |
item.grantfulltext | open | - |
dc.relation.pages | 8484-8491 | - |
dc.relation.journalvolume | 66 | - |
dc.relation.journalissue | 17 | - |
dc.identifier.uri.fulltext | http://ntur.lib.ntu.edu.tw/bitstream/246246/163232/1/12.pdf | - |
item.openairetype | journal article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.fulltext | with fulltext | - |
item.grantfulltext | open | - |
item.languageiso639-1 | en_US | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | Biochemical Sciences | - |
crisitem.author.dept | Biochemical Sciences | - |
crisitem.author.orcid | 0000-0002-3703-2386 | - |
crisitem.author.parentorg | College of Life Science | - |
crisitem.author.parentorg | College of Life Science | - |
顯示於: | 生化科學研究所 |
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